Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.400 Biomarker PSYGENET Genetic variation at a single nucleotide polymorphism (SNP) in the mu-opioid receptor gene (OPRM1) of both humans and rhesus macaques Macaca mulatta has been associated with differential affinity to the endogenous ligand beta-endorphin as well as alterations in pain sensitivity, drug and alcohol dependence, and social behaviors.The new study by Higham et al. 21463027

2011
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human Effects of sepiapterin supplementation and NOS inhibition on glucocorticoid-induced hypertension. 20186125

2010
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human The glucocorticoid receptor is required for experimental adrenocorticotrophic hormone-induced hypertension in mice. 20659135

2010
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human The glucocorticoid receptor is required for experimental adrenocorticotrophic hormone-induced hypertension in mice. 20659135

2010
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human Effects of sepiapterin supplementation and NOS inhibition on glucocorticoid-induced hypertension. 20186125

2010
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0030193
Disease: Pain
Pain 		0.400 Biomarker CTD_human The endogenous opioid beta-endorphin is a known indicator of stress and pain. 20084599

2010
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0030193
Disease: Pain
Pain 		0.400 Therapeutic CTD_human The endogenous opioid beta-endorphin is a known indicator of stress and pain. 20084599

2010
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic CTD_human Vigabatrin and ACTH showed no significant difference in the initial treatment of infantile spasms. 20078871

2010
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Biomarker CTD_human Vigabatrin and ACTH showed no significant difference in the initial treatment of infantile spasms. 20078871

2010
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome 		0.400 Biomarker CTD_human Cushing's disease in dogs and humans. 19153526

2009
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.400 Biomarker CTD_human Cushing's disease in dogs and humans. 19153526

2009
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human Cushing's disease in dogs and humans. 19153526

2009
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human The role of 20-hydroxyeicosatetraenoic acid in adrenocorticotrophic hormone and dexamethasone-induced hypertension. 19458537

2009
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human Cushing's disease in dogs and humans. 19153526

2009
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human The role of 20-hydroxyeicosatetraenoic acid in adrenocorticotrophic hormone and dexamethasone-induced hypertension. 19458537

2009
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human Overall, the data establish that the alpha(2)-Na(+)-K(+)-ATPase ouabain-binding site is of central importance in the development of ACTH-induced hypertension. 18487447

2008
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human Overall, the data establish that the alpha(2)-Na(+)-K(+)-ATPase ouabain-binding site is of central importance in the development of ACTH-induced hypertension. 18487447

2008
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human Arachidonic acid metabolism in glucocorticoid-induced hypertension. 18067589

2008
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human Arachidonic acid metabolism in glucocorticoid-induced hypertension. 18067589

2008
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Biomarker CTD_human Pediatricians should be aware that cardiac dysfunction could be associated with ACTH therapy for West syndrome. 19039989

2008
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic CTD_human Pediatricians should be aware that cardiac dysfunction could be associated with ACTH therapy for West syndrome. 19039989

2008
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human Antioxidant vitamins and adrenocorticotrophic hormone-induced hypertension in rats. 17994356

2007
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human The aim of the present study was to investigate the effects of aspirin, a potent antioxidant, on adrenocorticotropic hormone (ACTH) and dexamethasone (Dex)-induced hypertension. 17954371

2007
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker CTD_human The aim of the present study was to investigate the effects of aspirin, a potent antioxidant, on adrenocorticotropic hormone (ACTH) and dexamethasone (Dex)-induced hypertension. 17954371

2007
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Therapeutic CTD_human Antioxidant vitamins and adrenocorticotrophic hormone-induced hypertension in rats. 17994356

2007