×
Entrez Id: 1312
Gene Symbol: COMT
COMT
Unipolar Depression
0.400
Biomarker
BEFREE
Catechol-o-methyltransferase (COMT ) and proline dehydrogenase (PRODH) mRNAs in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression .14618678 2004
×
Entrez Id: 1392
Gene Symbol: CRH
CRH
Unipolar Depression
0.600
Biomarker
BEFREE
CRH , stress, and major depression : a psychobiological interplay.15196881 2004
×
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
Unipolar Depression
0.310
GeneticVariation
BEFREE
Monocyte chemoattractant protein-1 (MCP1 ) promoter -2518 polymorphism may confer a susceptibility to major depressive disorder in the Korean population.15296827 2004
×
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
Unipolar Depression
0.310
Biomarker
PSYGENET
Monocyte chemoattractant protein-1 (MCP1 ) promoter -2518 polymorphism may confer a susceptibility to major depressive disorder in the Korean population.15296827 2004
×
Entrez Id: 4128
Gene Symbol: MAOA
MAOA
Unipolar Depression
0.400
GeneticVariation
BEFREE
MAO-A gene polymorphisms are associated with major depression and sleep disturbance in males.15486489 2004
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Unipolar Depression
0.060
AlteredExpression
BEFREE
Estrogen receptor alpha mRNA levels were reduced in the basomedial nucleus in major depressive disorder and bipolar disorder.15576061 2004
×
Entrez Id: 259217
Gene Symbol: HSPA12A
HSPA12A
Unipolar Depression
0.310
Biomarker
BEFREE
HSPA12A messenger ribonucleic acid was significantly reduced (p < .01; mean log2 optical density difference = -.84) across subjects with schizophrenia but not in the DLPFC of subjects with major depression or in monkeys chronically treated with haloperidol.15601604 2004
×
Entrez Id: 7166
Gene Symbol: TPH1
TPH1
Unipolar Depression
0.400
Biomarker
BEFREE
Tryptophan hydroxylase-1 association with MD is still debated.16165107 2006
×
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
Unipolar Depression
0.800
AlteredExpression
BEFREE
Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide .16192985 2006
×
Entrez Id: 317
Gene Symbol: APAF1
APAF1
Unipolar Depression
0.320
GeneticVariation
BEFREE
Apaf-1 variants encoded by APAF1 alleles that segregate with major depression in families linked to chromosome 12 shared a common gain-of-function phenotype in both assay systems.16231040 2006
×
Entrez Id: 317
Gene Symbol: APAF1
APAF1
Unipolar Depression
0.320
Biomarker
PSYGENET
Apaf-1 variants encoded by APAF1 alleles that segregate with major depression in families linked to chromosome 12 shared a common gain-of-function phenotype in both assay systems.16231040 2006
×
Entrez Id: 3569
Gene Symbol: IL6
IL6
Unipolar Depression
0.600
GeneticVariation
BEFREE
Interleukin-6 genetic polymorphism and Chinese major depression .16244501 2005
LOC110806262
Unipolar Depression
0.070
GeneticVariation
BEFREE
Serotonin transporter gene promoter region polymorphism associated with poststroke major depression .16525076 2006
×
Entrez Id: 4929
Gene Symbol: NR4A2
NR4A2
Unipolar Depression
0.310
Biomarker
BEFREE
Nurr1 protein in BA 9 was significantly lower in major depression (P<0.05) and lower at a trend level in schizophrenia (P=0.056) than in the controls.16631355 2006
×
Entrez Id: 4929
Gene Symbol: NR4A2
NR4A2
Unipolar Depression
0.310
Biomarker
PSYGENET
Nurr1 protein in BA 9 was significantly lower in major depression (P<0.05) and lower at a trend level in schizophrenia (P=0.056) than in the controls.16631355 2006
×
Entrez Id: 5027
Gene Symbol: P2RX7
P2RX7
Unipolar Depression
0.080
Biomarker
BEFREE
P2RX7 , a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder .16822851 2006
×
Entrez Id: 627
Gene Symbol: BDNF
BDNF
Unipolar Depression
0.600
GeneticVariation
BEFREE
Brain-derived neurotrophic factor gene polymorphism (Val66Met ) and citalopram response in major depressive disorder .16979146 2006
×
Entrez Id: 627
Gene Symbol: BDNF
BDNF
Unipolar Depression
0.600
GeneticVariation
BEFREE
Brain-derived neurotrophic factor (BDNF ) polymorphisms G196A and C270T are not associated with response to electroconvulsive therapy in major depressive disorder .17036259 2007
×
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
Unipolar Depression
0.600
AlteredExpression
BEFREE
5-HTTLPR biases amygdala activity in response to masked facial expressions in major depression .17406646 2008
×
Entrez Id: 1312
Gene Symbol: COMT
COMT
Unipolar Depression
0.400
GeneticVariation
BEFREE
Catechol-o-methyltransferase polymorphism and susceptibility to major depressive disorder modulates psychological stress response.17417063 2007
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Unipolar Depression
0.400
GeneticVariation
BEFREE
ABCB1 (MDR1 ) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder .17913323 2008
×
Entrez Id: 64077
Gene Symbol: LHPP
LHPP
Unipolar Depression
0.320
Biomarker
PSYGENET
LHPP SNPs were also associated with major depression in both Utah and Ashkenazi populations.18268499 2009
×
Entrez Id: 64077
Gene Symbol: LHPP
LHPP
Unipolar Depression
0.320
Biomarker
BEFREE
LHPP SNPs were also associated with major depression in both Utah and Ashkenazi populations.18268499 2009
SERPINE1
Unipolar Depression
0.310
Biomarker
PSYGENET
Plasminogen activator inhibitor-1 gene is associated with major depression and antidepressant treatment response.18794724 2008
LOC110806262
Unipolar Depression
0.070
GeneticVariation
BEFREE
Serotonin transporter gene promoter polymorphisms modify the association between paroxetine serotonin transporter occupancy and clinical response in major depressive disorder .18987562 2009