Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.400 Biomarker CTD_human Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer. 23845849

2013
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.400 Biomarker CTD_human EGCG enhances the therapeutic potential of gemcitabine and CP690550 by inhibiting STAT3 signaling pathway in human pancreatic cancer. 22348037

2012
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker CTD_human Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition. 25970160

2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker CTD_human Interferon-gamma-induced dephosphorylation of STAT3 and apoptosis are dependent on the mTOR pathway. 16427044

2006
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker CTD_human Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors. 14975756

2004
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 Biomarker CTD_human Expression of AFP and STAT3 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in AFP-producing gastric cancer cells. 23382965

2013
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.400 Biomarker CTD_human Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma. 26192917

2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0206180
Disease: Ki-1+ Anaplastic Large Cell Lymphoma
Ki-1+ Anaplastic Large Cell Lymphoma 		0.400 Biomarker CTD_human Aberrant expression of the transcriptional factor Twist1 promotes invasiveness in ALK-positive anaplastic large cell lymphoma. 22155737

2012
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0278510
Disease: Childhood Medulloblastoma
Childhood Medulloblastoma 		0.400 Biomarker CTD_human Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas. 19001435

2008
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0278876
Disease: Adult Medulloblastoma
Adult Medulloblastoma 		0.400 Biomarker CTD_human Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas. 19001435

2008
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.400 Biomarker CTD_human STAT-3 activity in chemically-induced hepatocellular carcinoma. 12957465

2003
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.400 Biomarker CTD_human Interestingly, ANDRO induces cell cycle arrest and apoptosis of pancreatic cancer cells by inhibiting STAT3 and Akt activation, upregulating the expression of p21(WAF1) and Bax, and downregulating the expression of cyclinD1, cyclinE, survivin, X-IAP and Bcl-2. 23845849

2013
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.400 Biomarker CTD_human Additionally, gemcitabine and CP690550 alone inhibited STAT3 target genes and synergized with EGCG to inhibit cell viability and induce apoptosis in pancreatic cancer cells. 22348037

2012
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 Biomarker CTD_human Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors. 14975756

2004
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 Biomarker CTD_human Additionally, recent pre-clinical studies suggested enzalutamide might have the potential adverse effect of inducing metastasis of prostate cancer cells via Stat3 activation. 25970160

2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 Biomarker CTD_human Interferon-gamma-induced dephosphorylation of STAT3 and apoptosis are dependent on the mTOR pathway. 16427044

2006
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 Biomarker CTD_human Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors. 14975756

2004
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.400 Biomarker CTD_human Hyperactive EGFR signaling through Stat3 and the Jak-Stat3 activity together promote ovarian cancer progression to cisplatin resistance and therefore represent targets for preventing the development of cisplatin resistance and the recurrent disease during cisplatin therapy in ovarian cancer. 21909139

2012
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.400 Biomarker CTD_human Hyperactive EGFR signaling through Stat3 and the Jak-Stat3 activity together promote ovarian cancer progression to cisplatin resistance and therefore represent targets for preventing the development of cisplatin resistance and the recurrent disease during cisplatin therapy in ovarian cancer. 21909139

2012
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.400 Biomarker CTD_human We found that HN3 and FaDu cells expressed strongly phosphorylated STAT3 on both tyrosine 705 and serine 727 residues as compared to other SCCHN cells. 27064016

2016
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker CTD_human Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors. 14975756

2004
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.400 Biomarker CTD_human Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells. 25061499

2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.370 Biomarker CTD_human Aberrant expression of miR-125a-3p promotes fibroblast activation via Fyn/STAT3 pathway during silica-induced pulmonary fibrosis. 30658076

2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0740391
Disease: Middle Cerebral Artery Occlusion
Middle Cerebral Artery Occlusion 		0.370 Biomarker CTD_human Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke. 21940958

2011
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.360 Biomarker CTD_human Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. 19028472

2009