Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 Biomarker CTD_human E-cadherin germline mutations in familial gastric cancer. 9537325

1998

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.500 Biomarker CTD_human

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.400 Biomarker CTD_human Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years. 11397402

2001

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.400 Biomarker CTD_human DNA adduct measurements, cell proliferation and tumor mutation induction in relation to tumor formation in B6C3F1 mice fed coal tar or benzo[a]pyrene. 10874023

2000

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.360 Biomarker CTD_human Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. 22484628

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.360 Biomarker CTD_human Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. 24816253

2014

Entrez Id: 4595
Gene Symbol: MUTYH
MUTYH
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.320 Biomarker CTD_human

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.320 Biomarker CTD_human

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.310 Biomarker CTD_human Folate levels in mucosal tissue but not methylenetetrahydrofolate reductase polymorphisms are associated with gastric carcinogenesis. 17171786

2006

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.310 Biomarker CTD_human Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy. 21173787

2012

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.310 Biomarker CTD_human Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy. 21173787

2012

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.310 Biomarker CTD_human A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. 21364753

2011

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.310 Biomarker CTD_human MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. 22042947

2011

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.310 Therapeutic CTD_human "Gefitinib (""Iressa"", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells." 15723263

2005

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.310 Biomarker CTD_human "Gefitinib (""Iressa"", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells." 15723263

2005

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.310 Therapeutic CTD_human Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy. 21173787

2012

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.310 Therapeutic CTD_human MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. 22042947

2011

Entrez Id: 1496
Gene Symbol: CTNNA2
CTNNA2
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.300 Biomarker CTD_human Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. 24816253

2014

Entrez Id: 2023
Gene Symbol: ENO1
ENO1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.300 Biomarker CTD_human Diverse proteomic alterations in gastric adenocarcinoma. 15378696

2004

Entrez Id: 5480
Gene Symbol: PPIC
PPIC
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.300 Biomarker CTD_human Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. 16367923

2006

Entrez Id: 6257
Gene Symbol: RXRB
RXRB
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.300 Biomarker CTD_human A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. 21364753

2011

Entrez Id: 51292
Gene Symbol: GMPR2
GMPR2
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.300 Biomarker CTD_human Diverse proteomic alterations in gastric adenocarcinoma. 15378696

2004

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.300 Biomarker CTD_human Capsaicin consumption, Helicobacter pylori CagA status and IL1B-31C>T genotypes: a host and environment interaction in gastric cancer. 22414649

2012

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.300 Therapeutic CTD_human Effects on tumour microcirculation in mice of misonidazole and tumour necrosis factor plus hyperthermia. 1733439

1992

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.300 Biomarker CTD_human Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. 16367923

2006