|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
While expression of PGC-1alpha and many of its mitochondrial target genes are decreased in the skeletal muscle of patients with type 2 diabetes, no causal relationship between decreased PGC-1alpha expression and abnormal glucose metabolism has been established.
|
17932564 |
2007 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
We measured the metabolic parameters and the expression of PPARgamma and PGC-1alpha mRNA using quantitative real-time PCR in omental and subcutaneous (SC) adipose tissues in an observational study of 153 individuals as well as in SC fat and skeletal muscle in an interventional study of 60 subjects (20 each with normal glucose tolerance, impaired glucose tolerance, and T2D) before and after intensive physical training for 4 weeks.
|
19966034 |
2010 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
Patients with T2DM had significantly increased 8-OHdG and TUNEL labeling index and non-significant increases in the expression of PGC1-α and Tfam.
|
21281975 |
2011 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
HG-HF significantly depressed expression of PGC-1α (peroxisome proliferator-activated receptor-γ coactivator-1α) and OPA1 (optic atrophy 1) by reducing [Ca<sup>2+</sup>]<sub>i</sub>, whereas OPA1 supplementation partly reversed those detrimental effects induced by TRPV1<sup>-/-</sup> Furthermore, capsaicin treatment not only attenuated CMECs injury induced by HG-HF but also mitigated cardiac microvascular injury induced by T2DM.
|
29735636 |
2018 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
This review focuses on the role of PGC-1alpha in glucose metabolism and considers how PGC-1alpha links cellular glucose metabolism, insulin sensitivity and mitochondrial function, and why defects in PGC-1alpha expression and regulation may contribute to the pathophysiology of type 2 diabetes in humans.
|
16752166 |
2006 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
This study aimed to investigate whether genetic variations in human PPARGC1 gene are associated with metabolic syndrome-related phenotypes and T2D among obese subjects.
|
16122961 |
2006 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
In conclusion, these results indicated that these two variations in the PGC-1alpha gene might not contribute to the risk of hypertension and type 2 diabetes in the Chinese population studied here.
|
15824463 |
2004 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Multivariate model analysis, including T2D status, age, and body mass index (BMI), displayed significant covariance in PPARGC-1α rs8192678; SIRT1 rs7896005; TCF7L2 rs7903146 and rs122243326; UCP3 rs3781907; and HHEX rs1111875 with a P < 0.05.
|
31759989 |
2020 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
Our results demonstrated that a novel small molecule selectively elevated the expression of PGC-1α in myotubes and skeletal muscle and exerted promising therapeutic effects for treating type 2 diabetes.
|
23250358 |
2013 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
The objective of the study was to o investigate the relationship of the Gly482Ser (G482S) polymorphism in the peroxisome proliferator-activated receptor gamma coactivator-1alpha (PPARGC1A) gene and type 2 diabetes mellitus (T2DM), obesity, and oxidative status in Chinese adults.
|
19913841 |
2010 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
An interaction between ERRα and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) has also recently been shown to regulate an enzyme in the β-oxidation of free fatty acids, thereby suggesting that ERRα plays an important role in obesity and type 2 diabetes.
|
29216352 |
2018 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
Furthermore, our research pinpoints the role of several new T2D-associated genes (such as Srebf1 and Ppargc1) in the human population.
|
25758573 |
2014 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Genetic variation in the peroxisome proliferator-activated receptor (PPAR) and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC1) gene families and type 2 diabetes.
|
24359475 |
2014 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
The rs2454206" genes_norm="54790">p.Ile1762Val substitution (TET2-rs2454206) was associated with liver PPARGC1A-methylation and transcriptional levels, and Type 2 diabetes.Our results suggest that 5-hmC might be involved in the pathogenesis of NAFLD by regulating liver mitochondrial biogenesis and PPARGC1A expression.
|
26356709 |
2015 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
Alterations in the mitochondrial regulatory pathways constituted by the nuclear co-factors PGC-1alpha or PGC-1beta and mitofusin 2 in skeletal muscle in type 2 diabetes.
|
20175989 |
2011 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
The effect of exercise on epigenetic modifications of PGC1: The impact on type 2 diabetes.
|
24703492 |
2014 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
The present study demonstrates that the AA genotype of the Gly482Ser polymorphism in the PPARGC1 gene might be a risk factor for diabetic retinopathy in the Slovene population (Caucasians) with type 2 diabetes (odds ratio 2.7, 95% confidence interval 1.0-6.8), whereas the Pro12Ala polymorphism of the PPARgamma gene failed to confer susceptibility to diabetic retinopathy.
|
15782399 |
2005 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
There was no strong association between SNPs or haplotypes of PPARGC1A and type 2 diabetes.
|
15937669 |
2005 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
The impact of six polymorphisms of PGC-1α with Type 2 Diabetes (T2D) susceptibility was evaluated on 1125 samples comprising of 554 T2D cases and 571 controls among three endogamous groups (Bania, Brahmin and Jat Sikh) of North-West India (Punjab).
|
29063962 |
2018 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Thermogenic genes expressions in epicardial adipose tissue (UCP1: OR 0.617, 95%CI 0.103-0.989, p=0.042; PGC1α: OR 0.416, 95%CI 0.171-0.912, p=0.031; PRDM16: OR 0.643, 95%CI 0.116-0.997, p=0.044) were showed as protective factors against the presence of heart failure with reduced left ventricular ejection fraction, and age (OR 1.643, 95%CI 1.001-3.143, p=0.026), presence of coronary artery disease (OR 6.743, 95%CI 1.932-15.301, p<0.001) and type-2-diabetes mellitus (OR 4.031, 95%CI 1.099-7.231, p<0.001) were associated as risk factors.
|
28824327 |
2017 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
PGC-1alpha gene and physical activity in type 2 diabetes mellitus.
|
17031255 |
2006 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
The observation that PPARGC1A and the PPARs were upregulated in the adipose tissue of type 2 diabetic patients, along with the finding that adipose tissue from some patients with type 2 diabetes can express UCP1 mRNA, suggests that in these patients white adipose tissue may move towards a brown adipose tissue phenotype.
|
16538490 |
2006 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
The significant associations between PGC-1α polymorphisms and T2DM are also discussed in this review.
|
27094040 |
2016 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
A single nucleotide variant of the PPARGC1A gene (rs8192678) is associated with T2D susceptibility, relative risk of obesity and insulin resistance, and lower indices of β cell function.
|
29186342 |
2018 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Here, we assessed the association between the Gly482Ser variant of PPARGC1 and the arterial hypertension frequently found in subjects with type 2 diabetes.
|
15599700 |
2004 |