Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Ketamine suppressed the production of the only established depression-relevant proinflammatory cytokines, IL-6 and TNF?. 25903726

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Analyses for counselor report of child anxiety/depression symptoms on the Teacher Report Form indicated moderation of child maltreatment effects by triallelic 5-HTTLPR. 25422957

2015

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET We tested these mice along with C57BL/6 mice (Tph2C/C), congenic C57BL/6 mice homozygous for the Tph21473G-allele (Tph2G/G), and heterozygous Tph2-deficient mice (Tph2C/-) for anxiety- and depression-like behavior, and evaluated brain serotonin metabolism and 5-HT1AR signaling by high-performance liquid chromatography and quantitative autoradiography, respectively. 24863038

2015

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET The SS genotype of 5-HTTLPR was associated with increased depression scores after childhood abuse only in carriers of the low-expression TPH2 GG genotype, whereas the TPH2 AA genotype reversed this effect. 25214390

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Our findings reveal that 5-HTTLPR polymorphism modulates distressed feelings and brain activities associated with negative self-schema and suggest a potential neurogenetic susceptibility mechanism for depression. 23588187

2015

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Polymorphisms in the FK506 binding protein 5 (FKBP5) gene have been shown to influence glucocorticoid receptor sensitivity, stress response regulation, and depression risk in traumatized subjects, with most consistent findings reported for the functional variant rs1360780. 25522420

2015

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Pregabalin showed the analgesic effects but had no effects on either depression or the BDNF pathway. 25283187

2015

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET We investigated PTSD and depression severity, plasma cortisol, GR and mineralocorticoid receptor (MR) levels, and methylation status of NR3C1 and NR3C2 promoter regions in 25 women exposed to the Tutsi genocide during pregnancy and their children, and 25 women from the same ethnicity, pregnant during the same period but not exposed to the genocide, and their children. 24690014

2015

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Network modeling and animal experiments suggest that these genetic differences in GR-induced transcriptional activation may mediate the risk for depression and other psychiatric disorders by altering a network of functionally related stress-sensitive genes in blood and brain. 26050039

2015

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Among all candidate substrates, DPP4 displays highest affinity for NPY, an endogenous anxiolytic neurotransmitter that is suggested as a candidate biomarker in post-traumatic stress disorder (PTSD) and depression. 25635612

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET In vivo, the ablation of Casp6 results in a partial rescue of body weight gain, normalized IGF-1 levels, a reversal of the depression-like phenotype and decreased HTT levels. 25583186

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET These observations demonstrate that IL6 directly controls SERT levels and consequently serotonin reuptake and identify STAT3-dependent regulation of SERT as conceivable neurobiological substrate for the involvement of IL6 in depression. 25760924

2015

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Correlation analysis indicated that the alteration of multiple CRF-controlling receptors is highly correlated with depression-related behaviors of rats in the forced swimming test. 25578258

2015

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Our results confirm that the risk of depression conferred by childhood maltreatment is modified by variation at both SERT and BDNF genes. 25510949

2015

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children. 25422957

2015

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Bcl1 polymorphism of the glucocorticoid receptor gene and treatment response to milnacipran and fluvoxamine in Japanese patients with depression. 25358426

2015

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET The results of our analysis indicated no significant differences in the frequencies of the single alleles and genotypes of two polymorphisms in TPH2 gene between LOD patients and normal controls. 26057341

2015

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET We present here the current knowledge regarding the relation between chronic stress, BDNF and NMDARs and its implications in depression. 25277075

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Those with both the 5-HTTLPR s allele and the BDNF Met allele showed the highest risk of MD if they had previously experienced emotional (z = 2.08, p = 0.037), sexual (z = 2.19, p = 0.029) or any kind of childhood abuse (z = 2.37, p = 0.018). 25510949

2015

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Furthermore, the TPH2(-/-) mouse may serve as a useful model in the search for new medications that have therapeutic targets for depression that are outside of the 5HT neuronal system. 25089765

2015

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET The significantly higher homocysteine levels observed in MDD patients compared to controls after adjustment for age and sex (p?=?0.030), therefore appears to be mediated by the effects of MTHFR 677 C > T and low folate intake on BMI. 24532086

2015

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Using a recombinant adeno-associated viral (rAAV) vector, we addressed this idea by testing effects on anxiolytic- and depression-like behaviours in adult mice after overexpression of NPY transgene in the amygdala and/or hippocampus, two brain regions implicated in emotional behaviours. 25267070

2015

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Methylation in CpG sites in candidate genes were not predictors of depression at significance levels corrected for whole genome testing, but maltreated and control children did have significantly different ? values after Bonferroni correction at multiple methylation sites in these candidate genes (e.g., BDNF, NR3C1, FKBP5). 24655651

2015

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET These findings support the 'differential-susceptibility' hypothesis, whereby the BDNF Val allele modulates the influence of environmental stress on depression by enhancing the neuroplastic response to all life events. 22931410

2015

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET In conclusion results of present meta-analysis supports that there is a significant association between MTHFR C677T polymorphism and depression risk, and MTHFR 677T allele contributes to increased risk of depression in Asian individuals. 26177556

2015