Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Squamous cell carcinoma of the head and neck
0.800 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Squamous cell carcinoma of the head and neck
0.800 CausalMutation CLINVAR Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10. 11801303

2002

Entrez Id: 3621
Gene Symbol: ING1
ING1
Squamous cell carcinoma of the head and neck
0.710 CausalMutation CLINVAR Of 34 informative cases of head and neck squamous cell carcinoma, 68% of tumors showed loss of heterozygosity at chromosome 13q33-34, where the ING1 gene is located. 10866301

2000

Entrez Id: 207
Gene Symbol: AKT1
AKT1
Squamous cell carcinoma of the head and neck
0.500 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Squamous cell carcinoma of the head and neck
0.500 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of the head and neck
0.500 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of the head and neck
0.500 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma of the head and neck
0.500 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of the head and neck
0.500 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2015

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of the head and neck
0.500 GeneticVariation CLINVAR Many observations show that there are abnormalities in the expression of epidermal growth factor receptor (EGFR) and/or its ligands in HNSCC with frequent activation of multiple pathways downstream EGFR, and unrelated to RAS mutation. 21531084

2011

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of the head and neck
0.500 GeneticVariation CLINVAR EGFR is an established therapeutic target in head and neck squamous cell carcinoma (HNSCC). 20415598

2010

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of the head and neck
0.500 GeneticVariation CLINVAR Elucidation mechanisms by which these different strategies inhibit EGFR function may enhance the development of more effective treatments for HNSCC and enable prospective identification of individuals who will benefit from EGFR inhibition. 20415598

2010

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of the head and neck
0.500 GeneticVariation CLINVAR Investigational EGFR-targeted therapy in head and neck squamous cell carcinoma. 20415598

2010

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of the head and neck
0.500 GeneticVariation CLINVAR The EGFR-targeting monoclonal antibody cetuximab (Erbitux, Imclone Systems, Inc., Branchburg, USA) was FDA-approved for use in HNSCC in 2006. 20415598

2010

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of the head and neck
0.500 GeneticVariation CLINVAR A literature search was performed to identify studies elucidating mechanisms of action of several approaches to targeting EGFR in HNSCC (monoclonal antibodies, tyrosine kinase inhibitors, antisense approaches, and ligand-toxin conjugates). 20415598

2010

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
Squamous cell carcinoma of the head and neck
0.420 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
Squamous cell carcinoma of the head and neck
0.180 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
Squamous cell carcinoma of the head and neck
0.180 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Squamous cell carcinoma of the head and neck
0.130 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
Squamous cell carcinoma of the head and neck
0.120 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
Squamous cell carcinoma of the head and neck
0.120 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 673
Gene Symbol: BRAF
BRAF
Squamous cell carcinoma of the head and neck
0.110 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 5879
Gene Symbol: RAC1
RAC1
Squamous cell carcinoma of the head and neck
0.110 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Squamous cell carcinoma of the head and neck
0.100 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 2033
Gene Symbol: EP300
EP300
Squamous cell carcinoma of the head and neck
0.100 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016