Source: CLINVAR

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 CausalMutation CLINVAR Assessment of epidermal growth factor receptor and K-ras mutation status in cytological stained smears of non-small cell lung cancer patients: correlation with clinical outcomes. 21572125

2011
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 CausalMutation CLINVAR Good clinical response to gefitinib in a non-small cell lung cancer patient harboring a rare somatic epidermal growth factor gene point mutation; codon 768 AGC > ATC in exon 20 (S768I). 20522446

2010
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 CausalMutation CLINVAR Second-line treatments after first-line gefitinib therapy in advanced nonsmall cell lung cancer. 19536777

2010
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 CausalMutation CLINVAR Comparing ICA-based and single-trial topographic ERP analyses. 20422446

2010
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 GeneticVariation CLINVAR Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy. 19147750

2009
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 CausalMutation CLINVAR Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy. 19147750

2009
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 CausalMutation CLINVAR Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma. 19096302

2009
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 GeneticVariation CLINVAR A novel EGFR nonsense mutation in a non-small-cell lung cancer (NSCLC) patient who did not derive any clinical benefit with combination chemotherapy and erlotinib. 18628075

2008
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 CausalMutation CLINVAR Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response. 18676761

2008
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 GeneticVariation CLINVAR EGFR somatic doublets in lung cancer are frequent and generally arise from a pair of driver mutations uncommonly seen as singlet mutations: one-third of doublets occur at five pairs of amino acids. 18372921

2008
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 GeneticVariation CLINVAR EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: implications in targeting therapy. 17653080

2008
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 CausalMutation CLINVAR EGFR point mutation in non-small cell lung cancer is occasionally accompanied by a second mutation or amplification. 16863509

2006
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 GeneticVariation CLINVAR Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. 16533793

2006
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 CausalMutation CLINVAR Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants. 16205628

2006
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 CausalMutation CLINVAR Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L. 17045698

2006
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 GeneticVariation CLINVAR Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. 16187797

2005
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 CausalMutation CLINVAR Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. 16187797

2005
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.130 CausalMutation CLINVAR High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan. 15623594

2004
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.110 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma 		0.100 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.100 GeneticVariation CLINVAR MEK inhibitors reverse resistance in epidermal growth factor receptor mutation lung cancer cells with acquired resistance to gefitinib. 23102728

2013
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.100 GeneticVariation CLINVAR Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer. 22753918

2012
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma 		0.100 GeneticVariation CLINVAR Gefitinib-sensitizing mutations in esophageal carcinoma. 16707764

2006
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.100 GeneticVariation CLINVAR