Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23401
Gene Symbol: FRAT2
FRAT2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.020 AlteredExpression BEFREE FRAT1 and FRAT2 genes, clustered in human chromosome 10q24, are human homologues to mouse proto-oncogene Frat1, which promotes carcinogenesis through activation of the WNT - beta-catenin - TCF signaling pathway. 11894125

2002
Entrez Id: 23401
Gene Symbol: FRAT2
FRAT2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.020 AlteredExpression BEFREE Over-expression of FRAT1 or FRAT2 lead to carcinogenesis through activation of WNT--beta-catenin--TCF signaling pathway. 11445844

2001
Entrez Id: 23401
Gene Symbol: FRAT2
FRAT2
CUI: C0023418
Disease: leukemia
leukemia 		0.010 AlteredExpression BEFREE Modulation of FRAT2 leads to concomitant changes in Rac activity, and transformation of Frat knockout hematopoietic progenitor cells by MLL fusions results in leukemias displaying reduced Rac activation and increased sensitivity to chemotherapeutic drugs. 23074275

2012
Entrez Id: 23401
Gene Symbol: FRAT2
FRAT2
CUI: C3888194
Disease: MIXED LINEAGE LEUKEMIA
MIXED LINEAGE LEUKEMIA 		0.010 AlteredExpression BEFREE Modulation of FRAT2 leads to concomitant changes in Rac activity, and transformation of Frat knockout hematopoietic progenitor cells by MLL fusions results in leukemias displaying reduced Rac activation and increased sensitivity to chemotherapeutic drugs. 23074275

2012
Entrez Id: 23401
Gene Symbol: FRAT2
FRAT2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 Biomarker BEFREE FRAT1 and FRAT2 are cancer-associated genes encoding GSK-3beta-binding proteins. 11445844

2001
Entrez Id: 23401
Gene Symbol: FRAT2
FRAT2
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.010 AlteredExpression BEFREE These results indicated that FRAT1 and FRAT2 genes were up-regulated together in several cases of human gastric cancer. 11445844

2001
Entrez Id: 23401
Gene Symbol: FRAT2
FRAT2
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.010 AlteredExpression BEFREE These results indicated that FRAT1 and FRAT2 genes were up-regulated together in several cases of human gastric cancer. 11445844

2001
Entrez Id: 23401
Gene Symbol: FRAT2
FRAT2
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.010 Biomarker BEFREE FRAT1 and FRAT2 are cancer-associated genes encoding GSK-3beta-binding proteins. 11445844

2001