Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.380 Biomarker CTD_human We provide evidence that approximately 27% of ERBB2-positive human breast cancer specimens display high expression of HES1, phospho-S6RP, and GLUT1. 20197467

2010
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.380 Biomarker CTD_human Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation. 21036696

2010
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.380 Biomarker CTD_human Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation. 21036696

2010
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.380 Biomarker CTD_human We provide evidence that approximately 27% of ERBB2-positive human breast cancer specimens display high expression of HES1, phospho-S6RP, and GLUT1. 20197467

2010
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.350 Biomarker CTD_human We first show that the Notch-1 receptor, as well as its downstream target Hes-1, is up-regulated with colon cancer progression, similar to other genes involved in chemoresistance. 19147571

2009
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.340 Biomarker CTD_human In this study, we showed that a high percentage of lung cancer lines expressed Jagged1, Notch receptors, and their transcriptional target genes (HES1, Hey1), suggesting that the Notch pathway plays an important role in lung cancer biology. 17804716

2007
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.330 Biomarker CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729

2010
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0025286
Disease: Meningioma
Meningioma 		0.320 Biomarker CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729

2010
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.310 Biomarker CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729

2010
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.310 Biomarker CTD_human Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model. 20197467

2010
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.310 Biomarker CTD_human Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation. 21036696

2010
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.310 Biomarker CTD_human Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers. 17804716

2007
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0041956
Disease: Ureteral obstruction
Ureteral obstruction 		0.300 Biomarker CTD_human The antihelmenthic phosphate niclosamide impedes renal fibrosis by inhibiting homeodomain-interacting protein kinase 2 expression. 28318631

2017
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0007873
Disease: Uterine Cervical Neoplasm
Uterine Cervical Neoplasm 		0.300 Biomarker CTD_human Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells. 25061499

2014
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.300 Biomarker CTD_human Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells. 25061499

2014
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.300 Biomarker CTD_human Notch signaling contributes to lung cancer clonogenic capacity in vitro but may be circumvented in tumorigenesis in vivo. 21994468

2011
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0028945
Disease: oligodendroglioma
oligodendroglioma 		0.300 Biomarker CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729

2010
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0205834
Disease: Meningiomas, Multiple
Meningiomas, Multiple 		0.300 Biomarker CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729

2010
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0206663
Disease: Neuroectodermal Tumor, Primitive
Neuroectodermal Tumor, Primitive 		0.300 Biomarker CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729

2010
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0259785
Disease: Malignant Meningioma
Malignant Meningioma 		0.300 Biomarker CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729

2010
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0279070
Disease: Adult Oligodendroglioma
Adult Oligodendroglioma 		0.300 Biomarker CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729

2010
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0280475
Disease: Childhood Oligodendroglioma
Childhood Oligodendroglioma 		0.300 Biomarker CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729

2010
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0280793
Disease: Mixed Oligodendroglioma-Astrocytoma
Mixed Oligodendroglioma-Astrocytoma 		0.300 Biomarker CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729

2010
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0281784
Disease: Benign Meningioma
Benign Meningioma 		0.300 Biomarker CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729

2010
Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C0334584
Disease: Spongioblastoma
Spongioblastoma 		0.300 Biomarker CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729

2010