Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 Biomarker BEFREE A binomial logistic regression was performed to evaluate Ranson's criteria and IL6, IL8, and IL10 (at admission and after 48 hours) in the course of AP. 31242405

2020

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 Biomarker BEFREE According to the experimental results, euphorbia kansui effectively reduced the expression of inflammation related cytokines, such as NF-κB, TNF-α, sTNFR, IL-6, and IL-8, in the serum of patients with severe acute pancreatitis. 30945511

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 GeneticVariation BEFREE This meta-analysis demonstrated a suggestive result that people who carried the risk A allele of the IL-8 rs4073 polymorphism may be more sensitive to acute pancreatitis. 31340771

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 GeneticVariation BEFREE We examined whether this IL8 polymorphism confers susceptibility to AP. 29215544

2018

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 AlteredExpression BEFREE The aim of this study was to evaluate the efficacy of early continuous veno-venous hemofiltration (CVVH) in decreasing the intra-abdominal pressure (IAP) and serum interleukin-8 (IL-8) level in severe acute pancreatitis (SAP) patients with abdominal compartment syndrome (ACS). 29073601

2017

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 GeneticVariation BEFREE We found that the IL-8 -251T/A polymorphism was associated with a higher susceptibility to acute pancreatitis in a Chinese population. 25730090

2015

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 Biomarker BEFREE The effect of lornoxicam on TLR2 and TLR4 messenger RNA expression and tumor necrosis factor-α, interleukin-6, and interleukin-8 secretion in patients with systemic complications of acute pancreatitis. 25872171

2015

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 GeneticVariation BEFREE We found that the IL-8 -251T/A polymorphism is associated with an increased risk of acute pancreatitis, and no significant association between IL-1βand IL-10 gene polymorphisms and risk of acute pancreatitis was detected. 26125871

2015

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 GeneticVariation BEFREE In summary, the current study suggests that the IL-8 -251 T/A polymorphism is associated with an increased risk of AP. 24072654

2013

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 GeneticVariation BEFREE No correlation is found between the IL-8-251 polymorphism and the liability of AP. 18837094

2008

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 Biomarker BEFREE Determination of the frequency of IL-8 polymorphism in acute pancreatitis may be informative and may provide further evidence concerning the role of IL-8 in the severe form of this disease. 17124436

2006