Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.080 Biomarker BEFREE Selective HMGCR inhibitor drugs such as statins, which increase the catabolism of plasma LDL and reduce the plasma concentration of cholesterol, have been investigated as a possible treatment for AD. 29077483

2018
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.080 GeneticVariation BEFREE Here, we evaluated the potential role of HMGCR (rs3846662) in AD-related pathology by assessing neuroimaging biomarkers. 26950278

2016
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.080 GeneticVariation BEFREE Previous reports identified that HMGCR rs3846662 polymorphism is associated with biosynthesis of cholesterol in AD pathology. 27009838

2016
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.080 GeneticVariation BEFREE In conclusion, HMGCR rs3846662 acts as a potent genetic modifier for AD risk, age of onset and conversion. 25023145

2015
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.080 GeneticVariation BEFREE Set IV 'AMI < age 40, AD < age 65' included risk alleles for HMGCR. 21098980

2011
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.080 GeneticVariation BEFREE We investigated the influence of the -911C>A polymorphism (rs3761740) in the hydroxy-methyl-glutaryl CoA reductase (HMGCR) gene promoter on basal and regulated transcription, plasma cholesterol levels and the association with AD. 20450896

2010
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.080 GeneticVariation BEFREE The potential importance of this mechanism in AD was investigated by genetic association, and it was found that HMGCR, a key gene in cholesterol metabolism and among those most strongly upregulated, was associated with AD risk. 19239419

2009
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.080 GeneticVariation BEFREE The CC genotype of the HMGCR gene was associated with a reduced risk of AD. 17284348

2007