Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 212
Gene Symbol: ALAS2
ALAS2
CUI: C0002871
Disease: Anemia
Anemia 		0.350 Biomarker RGD Expression of the hemoglobin beta chain complex (Hbb), aminolevulinic acid synthase 2 (Alas2), and cell division cycle 25 homolog B (Cdc25b) genes changed as a result of anemia induced by the myelosuppressive agents linezolid, cisplatin, and carboplatin, suggesting that these genes may be suitable biomarkers. 21296123

2011
Entrez Id: 212
Gene Symbol: ALAS2
ALAS2
CUI: C0002871
Disease: Anemia
Anemia 		0.350 GeneticVariation BEFREE C-terminal deletions in the ALAS2 gene lead to gain of function and cause X-linked dominant protoporphyria without anemia or iron overload. 18760763

2008
Entrez Id: 212
Gene Symbol: ALAS2
ALAS2
CUI: C0002871
Disease: Anemia
Anemia 		0.350 Biomarker BEFREE In addition, the results indicate that anemia in XLSA/A is caused by the accumulation of iron in a form that is not readily usable for heme synthesis. 17192393

2007
Entrez Id: 212
Gene Symbol: ALAS2
ALAS2
CUI: C0002871
Disease: Anemia
Anemia 		0.350 GeneticVariation BEFREE The anemia is associated with a previously unrecognized ALAS2 mutation (Arg436Trp) and is unresponsive to pyridoxine. 16735131

2006
Entrez Id: 212
Gene Symbol: ALAS2
ALAS2
CUI: C0002871
Disease: Anemia
Anemia 		0.350 GeneticVariation BEFREE The occurrence of anemia and iron overload may be discordant in women heterozygous for ALAS2 mutations. 15885606

2005
Entrez Id: 212
Gene Symbol: ALAS2
ALAS2
CUI: C0002871
Disease: Anemia
Anemia 		0.350 GeneticVariation BEFREE To elucidate how pyridoxine-refractory X-linked sideroblastic anemia (XLSA) develops, we analyzed the erythroid-specific 5-aminolevulinate synthase (ALAS-E) gene of a patient with the anemia. 9226183

1997
Entrez Id: 212
Gene Symbol: ALAS2
ALAS2
CUI: C0002871
Disease: Anemia
Anemia 		0.350 Biomarker HPO