Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0002871
Disease: Anemia
Anemia
0.500 GeneticVariation BEFREE DKD-related anemia developed earlier and was more severe than non-DKD-related anemia based on more complicated mechanisms, including greater bleeding tendency associated with antiplatelet effect, less O2 sensing due to autonomic neuropathy or renin-angiotensin-aldosterone system inhibitor use, inhibitory effect of inflammatory cytokines, urinary loss of erythropoietin (EPO), and poor response to EPO. 31453863

2019

Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0002871
Disease: Anemia
Anemia
0.500 GeneticVariation BEFREE These factors include: (1) activation of the renin-angiotensin-aldosterone system, (2) anemia, (3) hypercalcemia, hyperphosphatemia and increased levels of FGF-23, and (4) uremic toxins. 31551803

2019

Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0002871
Disease: Anemia
Anemia
0.500 Biomarker BEFREE Inhibition of the renin-angiotensin system in the cardiorenal syndrome with anaemia: a double-edged sword. 31490340

2019

Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0002871
Disease: Anemia
Anemia
0.500 GeneticVariation BEFREE Heterozygous mutations in the gene encoding renin (REN) cause autosomal dominant tubulointerstitial kidney disease (ADTKD), early-onset anaemia and hyperuricaemia; only four different mutations have been described in the published literature to date. 28701203

2017

Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0002871
Disease: Anemia
Anemia
0.500 GeneticVariation BEFREE In multivariate analysis, in the non-extremely elderly group, age (HR 1.027, P < 0.001), body mass index (HR 0.919, P < 0.001), New York Heart Association III or IV (HR 3.626, P < 0.001), preserved ejection fraction (HR 0.553, P < 0.001), anemia (HR 1.941, P < 0.001), β-blockers (HR 0.695, P = 0.028) and renin-angiotensin system inhibitors (HR 0.603, P = 0.001) were independent predictors for all-cause death. 28544166

2017

Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0002871
Disease: Anemia
Anemia
0.500 Biomarker BEFREE ADKTKD-REN is associated with signs of hyporeninemia: mild hypotension, mild hyperkalemia, anemia in childhood, and hyperuricemia and gout in the teenage years. 28284384

2017

Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0002871
Disease: Anemia
Anemia
0.500 GeneticVariation BEFREE A similar clinical syndrome causing the autosomal dominant inheritance of chronic kidney disease, hyperuricemia, and anemia has recently been attributed to mutations in the REN gene encoding renin. 21071970

2011

Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0002871
Disease: Anemia
Anemia
0.500 GeneticVariation BEFREE Within the kindred, we found affected individuals over 4 generations who carried the novel REN mutation and were characterized by significant anemia, hyperuricemia, and CKD. 21903317

2011

Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0002871
Disease: Anemia
Anemia
0.500 GeneticVariation BEFREE Patients with mutations in the REN gene encoding renin suffer from anemia in childhood, hyperuricemia, mild hyperkalemia, and progressive kidney disease. 20807609

2010

Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0002871
Disease: Anemia
Anemia
0.500 GeneticVariation BEFREE A novel REN gene mutation resulted in an alteration in the amino acid sequence of the renin signal sequence and caused childhood anemia, polyuria, and kidney disease. 21084044

2010

Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0002871
Disease: Anemia
Anemia
0.500 AlteredExpression BEFREE The aim of the present study was to determine possible mechanisms linking anemia to renin-angiotensin system activity in CHF patients. 16172283

2005

Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0002871
Disease: Anemia
Anemia
0.500 Biomarker CTD_human Participation of the renin-angiotensin system in the captopril-induced worsening of anemia in chronic hemodialysis patients. 3524928

1986

Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0002871
Disease: Anemia
Anemia
0.500 Biomarker HPO