Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 GeneticVariation BEFREE We identified a high frequency of mutations in PTEN (50%) and genes involved in the endometrial cancer-related molecular pathway, which involves the IL-7 signaling pathway (PIK3R1, n=1; AKT2, n=1; FOXO1, n=1). 26626801

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 AlteredExpression BEFREE LncRNA-GAS5 induces PTEN expression through inhibiting miR-103 in endometrial cancer cells. 26511107

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE Modeling glands with PTEN deficient cells and microscopic methods for assessing PTEN loss: endometrial cancer as a model. 25461816

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 AlteredExpression BEFREE Up-regulation of genes involved in the insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link polycystic ovarian syndrome and endometrial cancer. 26802879

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 AlteredExpression BEFREE PTEN expression in benign human endometrial tissue and cancer in relation to endometrial cancer risk factors. 26376893

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE MiR-205 inhibits cell apoptosis by targeting phosphatase and tensin homolog deleted on chromosome ten in endometrial cancer Ishikawa cells. 24929707

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 PosttranslationalModification BEFREE Rapid estrogen signaling negatively regulates PTEN activity through phosphorylation in endometrial cancer cells. 24844349

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 GeneticVariation BEFREE Association of specific PTEN/10q haplotypes with endometrial cancer phenotypes in African-American and European American women. 26026735

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE We also report that nuclear localization of FOXO1 correlated with PTEN mutational status irrespective of the PIK3CA status in endometrial cancer cell lines. 25698082

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE We examined the anti-tumor activity of olaparib, a PARP inhibitor, and its correlation between the sensitivity and status of PTEN in endometrial cancer cell lines. 24625059

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 GeneticVariation BEFREE Alterations in the PI3K pathway are prevalent in endometrial cancer due to PIK3CA mutation and loss of PTEN. 24561032

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE Also, the PTEN gene has been shown to play an important role in endometrial cancer and glioblastoma, although the role of PTEN in MM has yet to be established. 24081673

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 GeneticVariation BEFREE Although loss of PTEN is common in both LS and sporadic EC cases, there was a lack of additional mutations in LS-associated EC cases. 23760948

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 GeneticVariation BEFREE Activating mutations in FGFR2 have been identified as potential therapeutic targets in endometrial cancer, typically occurring alongside genetic alterations that disrupt the mTOR pathway, such as PTEN loss. 23468082

2013

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 AlteredExpression BEFREE Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis? 22005521

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE New routes to old places: PIK3R1 and PIK3R2 join PIK3CA and PTEN as endometrial cancer genes. 22586352

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 AlteredExpression BEFREE Furthermore, decreased expression of a miR-205 target PTEN was detected in endometrial cancer tissues compared to normal tissues. 22514717

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 AlteredExpression BEFREE mTOR inhibition with temsirolimus has encouraging single-agent activity in endometrial cancer which is higher in chemotherapy-naive patients than in chemotherapy-treated patients and is independent of PTEN status. 21788564

2011

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 GeneticVariation BEFREE Endometrial cancer and genetic variation in PTEN, PIK3CA, AKT1, MLH1, and MSH2 within a population-based case-control study. 21093899

2011

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE Treatment with olaparib in a patient with PTEN-deficient endometrioid endometrial cancer. 21468130

2011

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 AlteredExpression BEFREE Prognostic value of microsatellite instability (MSI) and PTEN expression in women with endometrial cancer: results from studies of the NCIC Clinical Trials Group (NCIC CTG). 20304627

2010

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE Currently reported PTEN knockout mouse models initiate type I endometrial cancer concomitant with loss of PTEN in both uterine epithelium and stroma. 20855612

2010

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE The most frequent genetic alteration of endometrioid endometrial cancer is PTEN. 19078924

2009

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 GeneticVariation BEFREE Normal-appearing PTEN mutated endometrial glands, which are highly prevalent in the normal population, may be targets of endometrial cancer risk-modulating exposures. 19280590

2009

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 GeneticVariation BEFREE Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss. 17924977

2007