Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.470 Biomarker BEFREE Immunogenetic studies have identified polymorphisms of the IL-12/STAT4 pathway as being associated with PBC. 31803181

2019
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.470 PosttranslationalModification BEFREE This effect was mediated by the rapid and strong phosphorylation of STAT4 on Treg cells from patients with PBC and pSS (p < 0.05) but not PSC and HC. 30119881

2018
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.470 GeneticVariation GWASCAT A genome-wide association study identifies six novel risk loci for primary biliary cholangitis. 28425483

2017
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.470 Biomarker BEFREE Potential functional implications of key findings are discussed including the IL-12/STAT4 pathway in PBC and the CD28/IL-2 pathway in PSC. 26347073

2016
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.470 GeneticVariation BEFREE The effect of ICOSLG and CXCR5 variants were concordant but the effect of STAT4, NFKB1 and IL12B variants were discordant for PBC and CD. 26084578

2015
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.470 GeneticVariation BEFREE STAT4 gene polymorphism has been shown to be associated with the antiviral response in chronic hepatitis C and drug-induced liver injury (DILI), primary biliary cirrhosis (PBC), HCV-associated liver fibrosis and in hepatocellular carcinoma (HCC). 25798064

2015
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.470 Biomarker BEFREE Our findings confirm that STAT4 is involved in PBC susceptibility and may play a role in ANA status in the Japanese population. 24648611

2014
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.470 GeneticVariation GWASCAT Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. 23000144

2012
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.470 GeneticVariation GWASDB Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. 22961000

2012
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.470 GeneticVariation GWASDB Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. 23000144

2012
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.470 GeneticVariation GWASDB Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants. 22936693

2012
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.470 GeneticVariation BEFREE Among 21 non-HLA susceptibility loci for PBC identified in GWASs of individuals of European descent, three loci (IL7R, IKZF3, and CD80) showed significant associations (combined p = 3.66 × 10(-8), 3.66 × 10(-9), and 3.04 × 10(-9), respectively) and STAT4 and NFKB1 loci showed suggestive association with PBC (combined p = 1.11 × 10(-6) and 1.42 × 10(-7), respectively) in the Japanese population. 23000144

2012
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.470 GeneticVariation GWASCAT Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. 22961000

2012
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.470 Biomarker CTD_human Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. 21399635

2011