Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE The percentages of CC, CT and TT genotypes for MTHFR rs1801133 were 64.1%, 29.8% and 6.1% in the CRC group and 51.1%, 37.0% and 11.9% in the control group, respectively (p for trend=0.0006). 29599316

2018

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE We genotyped MTHFR polymorphisms C677T (rs1801133) and A1298C (rs1801131) for 498 CRC patients treated with 5-FU-based chemotherapy after receiving surgery. 28044213

2017

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Genetic variants in 3'-UTRs of methylenetetrahydrofolate reductase (MTHFR) predict colorectal cancer susceptibility in Koreans. 26046315

2016

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Evaluation of association studies and meta-analyses of MTHFR gene polymorphisms in colorectal cancer. 25823789

2016

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE In summary, this meta-analysis suggests that MTHFR A1298C polymorphism is associated with increased cervical cancer and lymphoma risk in Asians, and MTHFR A1298C polymorphism is associated with decreased colorectal cancer risk in Asians. 26156333

2016

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Using a nondominant model, the AA genotype for MTHFR rs1476413 exhibited a marginally significant (OR = 1.56; 95% CI = 1.00-2.44) association with CRC. 23893618

2014

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE MTHFR Glu429Ala and ERCC5 His46His polymorphisms are associated with prognosis in colorectal cancer patients: analysis of two independent cohorts from Newfoundland. 23626689

2013

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Quantitative assessment of the association between MTHFR C677T polymorphism and colorectal cancer risk in East Asians. 22890827

2013

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE The 677C>T (rs1801133) polymorphism in the MTHFR gene contributes to colorectal cancer risk: a meta-analysis based on 71 research studies. 23437053

2013

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE This systematic review synthesizes these data, highlighting the consistent inverse association between MTHFR 677TT genotype and risk of colorectal cancer (CRC) and its null association with adenoma risk. 23401104

2013

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Collectively, this meta-analysis suggested that MTHFR 677T allele might provide protection against CRC in worldwide populations, while MTRR 66G allele might increase the risk of CRC in Caucasians. 22719222

2012

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Plasma folate, methylenetetrahydrofolate reductase (MTHFR), and colorectal cancer risk in three large nested case-control studies. 22367721

2012

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Dietary intake of folate and alcohol, MTHFR C677T polymorphism, and colorectal cancer risk in Korea. 22218157

2012

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE However, MTHFR c.677C>T homozygosity with lifelong hyperhomocysteinemia and hence hypomethylation associate with increased risk of esophagus and gastric cancer, and with decreased risk of colorectal cancer. 20473868

2011

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic. 21211571

2011

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Homocysteine could be considered as a tumor marker in SHMT1 1420 wild-type (CC) CRC patients in Dukes' stage C and D. Further studies need to clarify why SHMT1 and MTHFR polymorphisms are associated only with rectal and not colon cancer risk. 20920350

2011

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Factor V Leiden (rs6025), prothrombin G20210A (rs1799963), PAI-1 4G/5G (rs1799889), MTHFR 677C>T (rs1801133), fibrinogen gamma 10034C>T (rs2066865), and factor XIII Val34Leu (rs5985) were genotyped in 1,801 patients with colorectal cancer and 1,853 healthy controls from a large German population-based study. 21422408

2011

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE We related prediagnostic plasma folate, vitamin B12, and total homocysteine concentrations, and the MTHFR 677C>T and 1298A>C polymorphisms, to the risk of colorectal cancer with and without the CpG island methylator phenotype (CIMP). 20012180

2010

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Although MTHFR C677T was associated with increased risks of colorectal cancer, leukemia, and gastric cancer, our pooled data suggest no evidence for a major role of MTHFR C677T in the carcinogenesis of childhood acute lymphoblastic leukemia. 20409583

2010

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Collectively, these exploratory data provide suggestive evidence for the association of MTHFR 429 Ala/ Ala and TCN2 259 Arg/Arg and CIMP status in colorectal cancer. 19936946

2010

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population. 20504332

2010

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE This large European prospective multicenter study did not show an association of CRC risk with plasma folate status nor with MTHFR polymorphisms. 20447924

2010

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Men with the MTHFR 677TT genotype were at decreased colorectal cancer risk (incidence rate ratio, 0.49; P = 0.01), but the T allele was associated with increased risk in women (incidence rate ratio, 1.39; P = 0.02). 19843671

2010

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE MTHFR gene polymorphisms and response to chemotherapy in colorectal cancer: a meta-analysis. 19663673

2010

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and FOLFOX response in colorectal cancer patients. 20078613

2010