Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Interaction between eNOS gene polymorphism and current smoking on susceptibility to coronary heart disease in Chinese people. 31567371

2020

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE The contribution of NOS3 variants to coronary artery disease: A combined genetic epidemiology and computational biochemistry perspective. 30447355

2019

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Odds ratios with 95% confidence intervals were used to evaluate associations between endothelial nitric oxide synthase polymorphisms and coronary artery disease. 30789045

2019

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE The association between an endothelial nitric oxide synthase gene polymorphism and coronary heart disease in young people and the underlying mechanism. 29359785

2018

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 Biomarker BEFREE Association between NOS3 <i>G894T, T-786C</i> and 4a/4b Variants and Coronary Artery Diseases in Iranian Population. 30788304

2018

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Assessment of the role of plasma nitric oxide levels, T-786C genetic polymorphism, and gene expression levels of endothelial nitric oxide synthase in the development of coronary artery disease. 28461820

2017

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Association of the Endothelial Nitric Oxide Synthase Gene T786C Polymorphism with In-Stent Restenosis in Chinese Han Patients with Coronary Artery Disease Treated with Drug-Eluting Stent. 28129392

2017

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Association Patterns of Endothelial Nitric Oxide Synthase Gene (NOS3) Variant Glu298Asp with Blood Pressure and Serum Lipid Levels in Subjects with Coronary Artery Disease from Pakistan. 28620990

2017

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Association between NOS3 genetic variants and coronary artery disease in the Han population. 27323132

2016

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Association of Cholesteryl Ester Transfer Protein and Endothelial Nitric Oxide Synthase Gene Polymorphisms With Coronary Artery Disease in the Multi-Ethnic Malaysian Population. 25667236

2016

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE In this study, we investigated the association between -786T/C polymorphism of the endothelial nitric oxide (NOS3) gene in which thymidine is replaced by a cytosine at nucleotide -786 (rs 2070744) and coronary collateral circulation (CCC) in patients with stable coronary artery disease. 26864067

2016

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE The results indicated that female sex, diabetes, and mutation in -786T/C eNOS gene correlate with ACh-provoked myocardial ischemia in patients with coronary spasm. 26656861

2015

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE We investigated the association of the T-786C single nucleotide polymorphism (SNP) of the endothelial nitric oxide synthase gene (NOS3), which is characterised by reduced expression of the enzyme in response to shear stress or interleukin-10 stimulation and significantly associated with coronary heart disease or rheumatoid arthritis, with the occurrence of isolated polymyalgia rheumatica. 26314610

2015

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Genetic etiology of coronary artery disease considering NOS 3 gene variant rs1799983. 25057159

2015

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Association between the - 786T>C 1polymorphism in the promoter region of endothelial nitric oxide synthase (eNOS) and risk of coronary artery disease: a systematic review and meta-analysis. 24135644

2014

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Association of endothelial nitric oxide synthase gene polymorphisms with coronary artery disease: an updated meta-analysis and systematic review. 25409023

2014

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Endothelial nitric oxide synthase (eNOS) 4b/a gene polymorphisms and coronary artery disease: evidence from a meta-analysis. 24810690

2014

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 Biomarker BEFREE Gene-gene interaction of ACE I/D, endothelial nitric oxide synthase 4 a/b and ApoE does not affect coronary artery disease severity. 24913112

2014

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE The nitric oxide (NO) synthase 3 (NOS3) gene is responsible for the synthesis of endothelial NO synthase (eNOS) in humans and some genetic polymorphisms are considered "polymorphisms associated with risk" for the development of coronary artery diseases, such as acute coronary syndrome. 23918902

2014

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: a meta‑analysis of 39 case‑control studies. 23443250

2013

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Association of the genetic variants of endothelial nitric oxide synthase gene with angiographically defined coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus. 23182401

2013

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Association of endothelial nitric oxide synthase gene variant (G894T) with coronary artery disease in Western Iran. 21602253

2012

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE The G894T polymorphism on endothelial nitric oxide synthase gene is associated with increased coronary heart disease among Asia population: evidence from a Meta analysis. 22417945

2012

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Strong interaction between T allele of endothelial nitric oxide synthase with B1 allele of cholesteryl ester transfer protein TaqIB highly elevates the risk of coronary artery disease and type 2 diabetes mellitus. 23157875

2012

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE In conclusion, the protective HO1 promoter polymorphism correlates with a lower coronary artery plaque burden, whereas the protective ENOS 894 G/T polymorphism seems to favourably influence changes of coronary artery plaque composition during statin therapy, but has no significant correlation to the magnitude of coronary atherosclerosis. 22123460

2011