Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1667
Gene Symbol: DEFA1
DEFA1
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.030 Biomarker BEFREE Alpha-defensins (α-Defs) in Crohn's disease: decrease of ileal α-Def 5 via permanent methylation and increase in plasma α-Def 1-3 concentrations offering biomarker utility. 29193023

2018
Entrez Id: 1667
Gene Symbol: DEFA1
DEFA1
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.030 GeneticVariation BEFREE Higher DEFA1A3 gene copy number (CD: mean copy number, 7.2 vs. controls 6.7; P < 0.001) and individual DEFA1 alleles (CD mean copy number 5.6 vs. controls 5.1; P < 0.01) were associated with CD, with strong association with colonic location (P < 0.001). 21701837

2011
Entrez Id: 1667
Gene Symbol: DEFA1
DEFA1
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.030 GeneticVariation BEFREE HNP-1 secretion depends on NOD2 stimulation by MDP-LD and contributes to antibacterial activity in intestinal epithelial cells expressing endogenous NOD2, but not NOD2 3020insC mutant associated with increased susceptibility to Crohn's disease. 19856414

2010