|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
BEFREE |
The most implicated gene is HLA-DRB1, with HLA-DRB1*03:01 the most associated risk allele in both Crohn's disease and ulcerative colitis.
|
31518029 |
2019 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
GWASCAT |
HLA-C*01 is a Risk Factor for Crohn's Disease.
|
26891255 |
2016 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
Biomarker |
CTD_human |
To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis.
|
25559196 |
2015 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
Biomarker |
BEFREE |
To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis.
|
25559196 |
2015 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
Biomarker |
BEFREE |
Depending on age categories compared, single nucleotide polymorphisms in POU5F1, TNFSF15, and HLA DRB1*501 were associated with age of Crohn's disease diagnosis.
|
25664710 |
2015 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
BEFREE |
We confirmed that the NKX2-3 polymorphism is associated with common susceptibility to IBD and that HLA-DRB1*0450 alleles increase susceptibility to CD but reduce risk for UC while HLA-DRB1*1502 alleles increase susceptibility to UC but reduce CD risk.
|
23942620 |
2014 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
|
23266558 |
2013 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
BEFREE |
These results show a significant association of the homozygous HLA-DRB1*07 genotype with UC and CD and of several HLA DR/DQ alleles and haplotypes with the clinical phenotypes of these diseases in Tunisian patients.
|
22224635 |
2012 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
BEFREE |
Haplotype-based analysis in the major histocompatibility complex region showed that HLA-Cw*1202-B*5201-DRB1*1502 haplotype was significantly associated with increased risk of UC compared with CD (P = 1.1 × 10⁻³³; OR = 6.58), accounting for most of the associations observed in the GWAS.
|
21699788 |
2011 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
BEFREE |
We confirmed that carriage of the HLA-DRB1*0103 allele is strongly associated with isolated colonic CD (14.9% versus 4.0%; P = 0.000016; OR 4.6, 95% CI 2.25-9.47) and report the novel association of this allele with time to first surgical event (log rank P = 0.001).
|
18521924 |
2008 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
BEFREE |
We were able to replicate the association of the IL23R variants with CD as well as HLA-DRB1*0103 with UC; confirmation of TNFRSF1A association with UC needs additional studies.
|
18338763 |
2008 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
BEFREE |
We conclude that BTNL2 does not contribute to the susceptibility to Japanese CD but is associated with Japanese UC because of the strong LD with HLA-DRB1*1502.
|
17610417 |
2007 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
BEFREE |
No significant associations were found between any FCRL3 SNP and CD or UC, but the stratification in patients with UC by human leukocyte antigen (HLA) showed a significant increase in heterozygosity at the FCRL3 locus, especially -169 AG (AG vs AA+GG, P= 0.0027, odds ratio = 3.6, 95% confidence interval 1.4-2.9), when HLA-DRB1*0103 carrier patients were compared with HLA-DRB1*0103 noncarriers.
|
17389014 |
2007 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
BEFREE |
As a whole, after applying Bonferroni's correction for multiple comparisons, no significant association of HLA-DRB1 alleles with Crohn's disease or ulcerative colitis was found.
|
15690658 |
2005 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
LHGDN |
A positive association between the HLA-DRB1*0103 allele and CD was detected in non-Jewish, familial cases (p = 0.0002), with risk for CD increased by 6.7 fold by the presence of an HLA-DRB1*0103 allele as compared to 1.9 fold and 19 fold by a single or two CARD15 variant alleles, respectively.
|
15046222 |
2004 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
BEFREE |
A positive association between the HLA-DRB1*0103 allele and CD was detected in non-Jewish, familial cases (p = 0.0002), with risk for CD increased by 6.7 fold by the presence of an HLA-DRB1*0103 allele as compared to 1.9 fold and 19 fold by a single or two CARD15 variant alleles, respectively.
|
15046222 |
2004 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
BEFREE |
The carrier frequency of the DRB1*0103 allele was found to be 10-fold higher in Crohn's disease patients with pure colonic involvement than in healthy controls (38.5% vs. 3.2%; p = 0.0002).
|
12656131 |
2003 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
Biomarker |
BEFREE |
Our previously reported association of DR1-DQ5 with CD was attributable to DRB1*0103.
|
10689124 |
2000 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
BEFREE |
These results indicated that both of HLA-DRB1 and TNFA promoter polymorphisms contribute to the susceptibility to CD in an independent manner.
|
11196680 |
2000 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
Biomarker |
BEFREE |
In conclusion, in CD in the Japanese population, HLA-linked disease susceptibility alleles appear to be DQB1*0402 and DRB1*1502, a disease resistance allele.
|
10323339 |
1999 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
BEFREE |
The DRB3*0301/DRB1*1302 haplotype is the only significant MHC class II association noted in white people with Crohn's disease and represents the strongest association of any MHC or non-MHC locus with this disease.
|
10189846 |
1998 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
Biomarker |
BEFREE |
The present study provides additional evidence for the genetic association between UC and HLA-DRB1*15, and supports recent findings that the susceptibility gene(s) for CD is not located in the HLA class II region.
|
9218841 |
1997 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
BEFREE |
The HLA-DRB1*07 was the only HLA class II allele found to be significantly associated with Crohn's disease (relative risk (RR) = 1.9, 95% CI: 1.66 to 2.14; p = 0.0001).
|
8707084 |
1996 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
BEFREE |
The strong negative association between the DRB1*03 allele and Crohn's disease suggests that the HLA-DRB1*03 allele mediates 'resistance' to Crohn's disease.
|
8881812 |
1996 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
Biomarker |
BEFREE |
Erosive polyarthritis and Crohn's disease. A case with HLA DRB1 determination.
|
7656474 |
1995 |