|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation |
BEFREE |
High-throughput sequencing of T-cell receptor complementarity-determining region 3 was carried out in male Pima Indians with normal glucose regulation (n = 11; age = 31 ± 8 years; %fat = 30.2 ± 8.7%) and the protective DRB1*02 haplotype versus those with T2DM without DRB1*02 (n = 7; age = 34 ± 8 years; %fat = 31.2 ± 4.7%).
|
26408818 |
2016 |
|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation |
BEFREE |
Overall, we did not find any evidence of susceptibility to ketosis associated with DRB1 and DQB1 genotypes (all P>0.05) in A(-) KPD compared to T2D.
|
25511714 |
2015 |
|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation |
BEFREE |
In Pima Indians, the HLA haplotype (HLA-DRB1*02) is protective against T2DM and, when studied when they have normal glucose tolerance, subjects with this HLA haplotype have higher insulin secretion compared to those without the protective haplotype.
|
26606528 |
2015 |
|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
VDR polymorphisms are present in T2DM, and correlate with HLA DRB1*04 and with immunologic and metabolic parameters; results from this study add T2DM to the list of diseases that are likely modulated by an HLA/VDR interaction.
|
22219324 |
2012 |
|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
HLA-DRB1*02 is protective for type 2 diabetes, probably by enhancing self tolerance, thereby protecting against the autoimmune-mediated reduction of insulin secretion.
|
21484216 |
2011 |
|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation |
BEFREE |
HLA DRB1, DQB1 and insulin promoter VNTR polymorphisms: interactions and the association with adult-onset diabetes mellitus in Czech patients.
|
18279373 |
2008 |
|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation |
LHGDN |
HLA DRB1, DQB1 and insulin promoter VNTR polymorphisms: interactions and the association with adult-onset diabetes mellitus in Czech patients.
|
18279373 |
2008 |
|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation |
BEFREE |
No significant differences were found between HLA-DRB1 alleles in T2DM vs. controls.
|
17341285 |
2007 |
|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation |
LHGDN |
[Study on the association between the HLA-DRB1 alleles and type 2 diabetes in Yi nationality of Yunnan].
|
17285557 |
2007 |
|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
LHGDN |
No significant differences were found between HLA-DRB1 alleles in T2DM vs. controls.
|
17341285 |
2007 |
|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
AlteredExpression |
BEFREE |
Platelet flow cytometry and allele-specific PCR revealed a significant correlation in type 2 diabetes between low platelet FcgammaRIIA expression and the 807TT genotype that is associated with increased platelet a(2)ss(1) receptor density.
|
16421008 |
2006 |
|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
The incidence of HLA-DRB1*1501 was found to be significant in type 2 diabetes and non-diabetic, particularly ASO-positive patients, compared to control subjects.
|
16611256 |
2006 |
|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation |
BEFREE |
We examined the effects of different HLA haplotypes on type 2 diabetes development by determining the DQA1 and DRB1 alleles of Hiroshima A-bomb survivors (111 diabetic patients and 774 controls) using the polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) method.
|
12941548 |
2003 |
|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation |
BEFREE |
Protective effect of DRB1 locus against type 2 diabetes mellitus in Mexican Mestizos.
|
12507821 |
2003 |
|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
These results suggest that TNFalpha is associated with a predisposition to progression to insulin dependency in GADab/DRB1*1502DQB1*0601-positive diabetic patients initially diagnosed with type 2 diabetes and that determination of these patients' TNFalpha genotype may allow for better prediction of their clinical course.
|
10999832 |
2000 |
|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation |
BEFREE |
Diabetic patients with DRB1*1502 are 8.8 times more likely to develop ESRD, independently of the duration time of DM.
|
11082516 |
2000 |
|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation |
BEFREE |
Our aim was to determine (i) the prevalence of DRB1 and DQB1 genotypes in patients at diagnosis of Type II diabetes at different ages from 25 to 65 years compared with the general population, and (ii) whether the presence of islet cell antibodies (ICA) or glutamic acid decarboxylase antibodies (GADA) or both by age is associated with different DRB1 and DQB1 genotypes.
|
10333055 |
1999 |
|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation |
BEFREE |
The proportion of susceptible and resistant alleles to IDDM determined the degree of insulin deficiency, and comparison of IDDM to NIDDM well controlled by diet and/or sulfonylurea agents revealed significant differences in DRB1*0405 (P < 0.05; RR = 2.82 and RR = 0.89, respectively) and DRB1*1502 (P < 0.001; RR = 0.02 and RR = 2.19, respectively).
|
9475358 |
1998 |
|
HLA-DRB1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker |
BEFREE |
In addition, a combination of serological marker (anti-GAD) and genetic marker (HLA-DRB1) is useful for predicting clinical course of NIDDM patients with secondary failure of sulfonylurea agents.
|
9344701 |
1997 |