Of note, it has been described that polymorphisms in CD209, GSTM1, IL-10, IL-28B, MMP9, OAS2, OAS3, and TLR3 have a statistically significant impact on TBEV infection.
The serum concentration of TNFα was increased in TBE patients bearing a high-expression TLR3rs5743305 TT genotype, which also associated with the increased risk of TBE.
Previously, we reported an association between seven single nucleotide polymorphisms (SNPs) in four innate immunity genes (OAS2, OAS3, CD209, and TLR3) and human predisposition to tick-borne encephalitis, caused by a virus from the same Flaviviridae family, in a Russian population.
These results indicate that the G allele (within the G/G homozygous genotype) of the TLR3rs3775291 SNP is associated with predisposition to TBE in the Russian population.