Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
CUI: C0018801
Disease: Heart failure
Heart failure 		0.040 GeneticVariation BEFREE Based on animal models, Substance P is highly associated with the development of cardiomyopathies, subsequently leading to heart failure. 31103623

2019
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
CUI: C0018801
Disease: Heart failure
Heart failure 		0.040 GeneticVariation BEFREE We sought to directly monitor cAMP in a microdomain formed around sodium-potassium ATPase (NKA) in healthy and failing cardiomyocytes and to better understand alterations of cAMP compartmentation in heart failure. 30165515

2019
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
CUI: C0018801
Disease: Heart failure
Heart failure 		0.040 Biomarker BEFREE The improvement of heart function in HF mice treated with ERβ agonist DPN was also associated with reduced cardiac fibrosis and increased cardiac angiogenesis, while the ERα agonist PPT had no significant effect on either cardiac fibrosis or angiogenesis. 30376877

2018
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
CUI: C0018801
Disease: Heart failure
Heart failure 		0.040 Biomarker BEFREE Second, this review explores other hormones that are augmented by sacubitril/valsartan such as bradykinin, substance P and adrenomedullin that may contribute to the efficacy of sacubitril/valsartan in HF. 28689178

2017