DisGeNET - a database of gene-disease associations

Source: ALL

Disease: Intestinal Neoplasms ×

Gene: MTCO2P12 ×

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Gene

Disease

Score _gda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

Entrez Id:	107075310
Gene Symbol:	MTCO2P12

MTCO2P12

CUI:	C0021841
Disease:	Intestinal Neoplasms

Intestinal Neoplasms

0.030

AlteredExpression

BEFREE

Moreover, a single copy deletion of CXCR2 gene resulted in abrogation of COX-2 and Gro-α upregulation in intestinal tumors caused by the APC mutation.

24338666

2014

Entrez Id:	107075310
Gene Symbol:	MTCO2P12

MTCO2P12

CUI:	C0021841
Disease:	Intestinal Neoplasms

Intestinal Neoplasms

0.030

Biomarker

BEFREE

These results strongly suggest that COX-2 contributes to the development of intestinal tumors and that inhibition of COX is chemo-preventative.

10668484

1999

Entrez Id:	107075310
Gene Symbol:	MTCO2P12

MTCO2P12

CUI:	C0021841
Disease:	Intestinal Neoplasms

Intestinal Neoplasms

0.030

AlteredExpression

BEFREE

COX-2 is expressed at high levels in intestinal tumors in humans and rodents.

9151799

1997