Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker BEFREE This robust automated bright-field dual in situ hybridization assay for the simultaneous detection of PIK3CA and CHR3 centromere provides a potential clinical diagnostic method to assess PIK3CA gene abnormality in lung tumors. 26163898

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 GeneticVariation BEFREE Using GEM models, we tested whether PI3'-lipid signaling was limiting for the promotion of KRAS(G12D)-driven lung tumors by inducing the expression of KRAS(G12D) in the absence and presence of the activating PIK3CA(H1047R) mutation. 26567140

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker BEFREE Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance. 24229709

2014

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker BEFREE The PI3K/AKT pathway is thus a major pathway contributing to gefitinib resistance in lung tumors with KRAS mutation, through the regulation of the BAX/Ku70 interaction. 24374738

2014

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 GeneticVariation BEFREE We first observed that PD-0325901 at 1.5 mg/kg SID and in combination with PF-04691502 (7.5 mg/kg; SID) significantly inhibited growth of H460 (carry Kras and PIK3CA mutations) orthotopic lung tumors. 22684718

2012

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 AlteredExpression BEFREE The study suggests that HPV infection-induced IL-17 levels can stimulate Mcl-1 expression through the PI3K pathway and promote lung tumor cell progression through a p53- and IL-6-independent pathway. 20578176

2010

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 GeneticVariation LHGDN inhibitors of the PI3K-mTOR pathway may be active in cancers with PIK3CA mutations and, when combined with MEK inhibitors, may effectively treat KRAS mutated lung cancers 19029981

2008

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker LHGDN There was significant difference in survival between the lung cancer patients with PIK3CA normal copy number and the patients with PIK3CA amplification 17681398

2008

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 GeneticVariation LHGDN RNA interference-mediated knockdown of PIK3CA inhibited colony formation of cell lines with PIK3CA mutations or gains but was not effective in PIK3CA wild-type cells/mutations or gains are present in a subset of lung cancers 18757405

2008

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 GeneticVariation BEFREE Actually, among the surgically resected lung tumors, the adenocarcinomas with the K-ras gene mutation tended to show a higher frequency and intensity of immunoreactivity for phosphorylated Akt (p-ser473Akt) than those without the mutation, supporting the in vitro observation that the mutated K-ras can activate the PI3K-Akt pathway. 14695323

2004

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 CausalMutation CGI

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker CTD_human