|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
AlteredExpression |
BEFREE |
IFNα upregulated HLA-DRB1 expression on lupus but not control CD8+ T cells.
|
30674474 |
2019 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation |
BEFREE |
The aim of the study was to explore whether TGF-β and IL-6 gene polymorphisms may be associated with SLE and assess the frequency of HLA-DRB1 alleles in Polish systemic lupus erythematosus (SLE) patients.
|
30943147 |
2019 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation |
BEFREE |
In this cohort, SNP rs9271366 (tag SNP for HLA-DRB1*15:01) confers the highest risk for SLE among the 13 MHC gene alleles that display association with SLE (p = 8.748E-10; OR = 3.5).
|
31032751 |
2019 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation |
BEFREE |
Our results confirm the association between TNF and DRB1 polymorphisms and SLE.
|
29912900 |
2018 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker |
BEFREE |
This study demonstrated that the presence of HLA-DRB1*15 was a strong factor that predisposed patients to the development of SLE and LN, but did not influence kidney graft survival.
|
29421495 |
2018 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker |
BEFREE |
Next-generation sequencing analysis of the MHC region (previously suggested to be a hot region in atypical psychosis) using HLA typing (HLA-DRB1) revealed a common vulnerability with SLE (systemic lupus erythematosus) among five patients.
|
30323194 |
2018 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker |
BEFREE |
The association of homozygous deletion of C4A and SLE is accompanied by the presence of HLA-DRB1*0301 without a proven pathophysiological mechanism.
|
29050534 |
2018 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker |
BEFREE |
Case-control studies on HLA-DRB1 and SLE were searched from PubMed, Elsevier Science, Springer Link, Medline, and Cochrane Library database as of June 2018.
|
30511687 |
2018 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation |
BEFREE |
Certain haplotype combinations, DRB1*07-DQβ1*03 (OR: 2.21; 95% CI:1.29-3.79, p<sub>c</sub> = 0.06, p = 0.00036) and DRβ1*07-DQβ1*05 (OR: 2.51, 95% CI: 1.34-4.71, p<sub>c</sub> = 0.07, p = 0.00039), had positive associations whereas DRβ1*14-DQβ1*03 (OR: 0.14, 95% CI: 0.061-0.36, p<sub>c</sub> = 2.34 × 10<sup>-5</sup>, p = 1.30 × 10<sup>-6</sup>) were found to have a significant negative association with SLE.
|
29439646 |
2018 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker |
BEFREE |
In conclusion, our observations showed that HLA-G 14bp ins allele represents a genetic contribution on early-onset SLE independent of DRB1.
|
27331404 |
2016 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation |
BEFREE |
Classic HLA allele imputation analysis identified HLA-DRB1*1501 and HLA-DQB1*0602, each highly correlated with one another, as most strongly associated with SLE.
|
26663301 |
2016 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation |
BEFREE |
Of all the HLA-DR beta chain paralogs, those encoded by HLA-DRB1 solely or dominantly influence susceptibility to RA and SLE.
|
26919467 |
2016 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation |
BEFREE |
We detected 6 HLA-DRB1 alleles that were associated with SLE in Koreans.
|
26663868 |
2016 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation |
BEFREE |
We found an increase in risk of maternal SLE associated with exposure to children who inherited DRB1*04:01 from their father (OR 1.9; 95% CI, 1.1-3.2), among *04:01 allele-negative mothers.
|
27388144 |
2016 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation |
BEFREE |
We further observed a consistent negative association of HLA-DRB1(∗)13 allele with SLE, Ps + PsA, RA, and SSc (18.3%, 19.3%, 16.3%, and 11.9%, resp., versus 29.8% in controls).
|
26605347 |
2015 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation |
BEFREE |
A total of 25 case-control studies on the relationship between gene polymorphism of HLA-DRB l and SLE were performed and data were analyzed and processed using Review Manager 5.2 and Stata 11.0.
|
25546242 |
2015 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker |
BEFREE |
Polymorphisms in several genes were associated with IL-6 levels (including IL10, TYK2, and CD40L in SLE and DRB1, NOD2, and CSF1 in RA) or with TNFα levels (including TNFSF4 and CSF2 in SLE and PTPN2, DRB1, and NOD2 in RA).
|
25652333 |
2015 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
SusceptibilityMutation |
ORPHANET |
Our data suggest an association between MHC class I and class II (HLA-A*29, HLA-B*51, HLA-DRB1*15, and HLA-DQB1*06) and susceptibility to SLE in the Saudi population.
|
23793423 |
2014 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation |
BEFREE |
The 7 SNPs and 4 HLA-DRB1 alleles associated with SLE did not display strong associations with ANA positivity.
|
25186300 |
2014 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker |
BEFREE |
CFH (P=8.41 × 10(-6)), HLA-DRA (P=4.91 × 10(-6)), HLA-DRB1 (P=9.46 × 10(-9)), PXK (P=3.62 × 10(-4)), BLK (P=9.32 × 10(-3)), and UBE2L3 (P=4.07 × 10(-3)) were identified as shared genes between IgAN and SLE.
|
24458077 |
2014 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker |
BEFREE |
Our results provide strong evidence for a multilevel risk model for HLA-DRB1*03:01 in SLE, where the association with anti-Ro and anti-La antibody-positive SLE is much stronger than SLE without these autoantibodies.
|
24598797 |
2014 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker |
BEFREE |
Significantly different carrier frequencies of certain DRB1 alleles were found to be associated with SLE as follows: increased DRB1*15:01 (P = 5.48×10⁻¹⁰, corrected P (Pc) = 1.59×10⁻⁸, odds ratio [OR] 2.17, 95% confidence interval [CI] 1.69-2.79), decreased DRB1*13:02 (P = 7.17×10⁻⁵, Pc = 0.0020, OR 0.46, 95% CI 0.34-0.63) and decreased DRB1*14:03 (P = 0.0010, Pc = 0.0272, OR 0.34, 95% CI 0.18-0.63).
|
24498373 |
2014 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker |
BEFREE |
An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes.
|
23407388 |
2013 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation |
GWASDB |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker |
BEFREE |
Interestingly, HLA-DRB1*09:01 has been shown to be associated with multiple autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus, suggesting that either HLA-DRB1*09:01 itself or other genes in tight linkage disequilibrium may play a role in a molecular pathway shared by various autoimmune diseases in Japanese and possibly in other Asian populations.
|
23180035 |
2013 |