Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.470 GeneticVariation BEFREE The <i>HLA-A*0201∼C*0602∼B*1302∼DRB1*0701∼DQB1*0201</i> haplotype was significantly associated with follicular lymphoma (FL) risk among Caucasians. 31215275

2019

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.470 Biomarker BEFREE We hypothesized that amino acids in HLA-antigen D-related β1 subunit (DRB1) interact with smoking in FL risk, as shown for rheumatoid arthritis. 28369180

2017

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.470 GeneticVariation BEFREE We confirmed that FL-protective rs2647012-linked variants, in high linkage disequilibrium with the extended haplotype DRB1*15:01-DQA1*01:02-DQB1*06:02, correlate with increased HLA-DQB1 expression. 24304973

2014

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.470 GeneticVariation BEFREE Coding variants at hexa-allelic amino acid 13 of HLA-DRB1 explain independent SNP associations with follicular lymphoma risk. 23791106

2013

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.470 SusceptibilityMutation ORPHANET Coding variants at hexa-allelic amino acid 13 of HLA-DRB1 explain independent SNP associations with follicular lymphoma risk. 23791106

2013

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.470 GeneticVariation GWASDB A meta-analysis of genome-wide association studies of follicular lymphoma. 23025665

2012

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.470 GeneticVariation BEFREE Extended haplotypes DRB1*01:01-DQA1*01:01-DQB1*05:01 (OR = 2.01, 95% CI = 1.22-3.38) and DRB1*15-DQA1*01-DQB1*06 (OR = 0.55, 95% CI = 0.36-0.82) also influenced FL risk. 22296171

2012

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.470 GeneticVariation BEFREE In a recent genome-wide association study of follicular lymphoma (FL), we identified novel risk alleles on chromosome 6p21.33 that appeared to be part of an extended haplotype including HLA-DRB1*0101, DQA1*0101, and DQB1*0501. 21133715

2011

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.470 Biomarker BEFREE Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008). 20385791

2010