|
HLA-DRB1
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
To scan the human melanoma differentiation antigens TRP-1 and TRP-2 for HLA-DRB1*0301-restricted CD4+ T cell epitopes we applied the following methodology: Splenocytes of HLA-DRB1*0301-transgenic mice immunized with recombinant adenovirus encoding TRP-1 (Ad5.TRP-1) or TRP-2 (Ad5.TRP-2) were tested for their T cell reactivity against combinatorial TRP-1- and TRP-2-specific peptide libraries.
|
21152437 |
2010 |
|
HLA-DRB1
|
melanoma
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, although an association with HLA-A, HLA-B, HLA-DRB1, or HLA-DQB1 was not demonstrated, the study of the HLA-C locus revealed that the analysis of the dimorphism at position 80 in the alpha1 helix may help to evaluate the risk and prognosis of melanoma in our population.
|
16365741 |
2006 |
|
HLA-DRB1
|
melanoma
|
0.100 |
GeneticVariation |
BEFREE |
HLA haplotype distribution showed statistically significant increased frequencies of A*01-B*35-Cw*04 (0.069 vs 0.000; pc < 0.05; OR = 19.9), A*01-B*08-DRB1*03 (0.079 vs 0.019; pc < 0.05; OR = 4.5), and A*24-B*40-DRB1*11 (0.026 vs 0.000; pc < 0.05; OR = 7.1) in melanoma patients compared with healthy controls.
|
15248031 |
2005 |
|
HLA-DRB1
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
A multivariate logistic regression model showed HLA-DRB1*04 to behave as an independent favorable prognostic marker of melanoma in our population (OR = 2.34, CI = 1.15-4.74).
|
15191529 |
2004 |
|
HLA-DRB1
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
White adults with cutaneous melanoma in central Alabama have a predominance of Irish, Scots, and "British Isles" ancestry and HLA-DRB1*04 that likely contributes to their high incidence of cutaneous melanoma.
|
15310399 |
2004 |
|
HLA-DRB1
|
melanoma
|
0.100 |
AlteredExpression |
BEFREE |
Among patients with localized melanoma, both HLA-DRB1*1101 and increased IFN-gamma levels were associated with an increased risk for recurrence; HLA-DRB1*1101-positive patients had relatively increased levels of IFN-gamma.
|
12095976 |
2002 |
|
HLA-DRB1
|
melanoma
|
0.100 |
AlteredExpression |
LHGDN |
Among patients with localized melanoma, both HLA-DRB1*1101 and increased IFN-gamma levels were associated with an increased risk for recurrence; HLA-DRB1*1101-positive patients had relatively increased levels of IFN-gamma.
|
12095976 |
2002 |
|
HLA-DRB1
|
melanoma
|
0.100 |
Biomarker |
LHGDN |
Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma.
|
12208877 |
2002 |
|
HLA-DRB1
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
We obtained a lytic CD4 T-cell clone that recognized an antigen presented by HLA-DRB1*1101 on the tumor cells of a melanoma patient who enjoyed an unusually favorable clinical evolution.
|
10987298 |
2000 |
|
HLA-DRB1
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
Bulk and cloned CD4+ T cells produced IFN-gamma specifically in response to, and also lysed, T2.DR4 cells pulsed with peptide NY-ESO-1(119-143) and the autologous tumor cell line, but not a DRB1*0401+ melanoma cell line that does not express NY-ESO-1.
|
10987311 |
2000 |
|
HLA-DRB1
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
To identify a gp100 epitope restricted by the MHC class II allele with the highest prevalence in patients with malignant melanoma (HLA-DRB1*0401), we immunized mice transgenic for a chimeric human-mouse class II molecule (DR4-IE) with recombinant human gp100 protein.
|
10725708 |
2000 |
|
HLA-DRB1
|
melanoma
|
0.100 |
GeneticVariation |
BEFREE |
We report here serologic and molecular analysis by polymerase chain reaction sequence-specific primers (PCR-SSP) and PCR sequence-specific oligonucleotides (PCR-SSO) of HLA class II DRB1 and DQB1 loci in 132 patients with melanoma and 102 ethnically matched controls.
|
9807738 |
1998 |
|
HLA-DRB1
|
melanoma
|
0.100 |
Biomarker |
BEFREE |
Our investigation was undertaken to analyze the relationship between HLA alleles distribution in patients with melanoma and susceptibility to the tumor, in order to study the possible correlation between HLA class II DQA1, DQB1 and DRB1 genes involved in immune recognition, and melanoma, usually considered a highly immunogenic tumor.
|
9550328 |
1998 |
|
HLA-DRB1
|
melanoma
|
0.100 |
AlteredExpression |
BEFREE |
The frequency of HLA-DQB1*0302 was increased, while those of DQA1*0101(04), -DQA1*0401 and DRB1*0802 were decreased in melanoma patients compared with controls.
|
9174138 |
1997 |
|
HLA-DRB1
|
melanoma
|
0.100 |
GeneticVariation |
BEFREE |
To determine whether melanoma risk is associated with HLA class II alleles, molecular oligotyping of HLA class II-DRB1, -DQA1 and -DQB1 genes was performed for 45 patients with melanoma.
|
7960221 |
1994 |