Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.080 Biomarker BEFREE Recent evidences showed that elevation of plasminogen activator inhibitor 1 (PAI-1) was responsible in mediating obesity-induced non-alcoholic fatty liver disease (NAFLD) and metabolic disorders. 29163785

2017
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.080 Biomarker BEFREE More and more evidences have shown that PAI-1 involves in physiopathologic mechanisms of many diseases and metabolic disorder. 28378106

2017
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.080 AlteredExpression BEFREE The plasma PAI-1 levels may be determined by the degree of obesity and TG metabolic disorders. 28692480

2017
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.080 Biomarker BEFREE Plasminogen activator inhibitor-1 and the circadian clock in metabolic disorders. 19387897

2009
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.080 Biomarker BEFREE PAI-1 is associated with fibrosis, thrombosis, and metabolic disorders. 17095240

2006
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.080 Biomarker BEFREE Obesity is a metabolic disorder that is associated with increased plasminogen activator inhibitor-1 (PAI-1) concentration in the circulation. 15853833

2005
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.080 Biomarker BEFREE However, in light of recent studies, visceral adipose tissue appears to be involved in the increase of plasma PAI-1 via the metabolic disorders usually associated with central obesity, rather than directly. 10867719

2000
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.080 GeneticVariation BEFREE A relationship between 4G/5G polymorphism and PAI-1 levels was found in patients with cardiovascular and metabolic diseases, but not in healthy subjects. 9869167

1998