|
HLA-DRB1
|
Neoplasms
|
0.100 |
GeneticVariation |
BEFREE |
The following 4 novel HLA alleles were identified in association with cervical neoplasia, owing to their linkage disequilibrium with known cervical neoplasia-associated HLA-DRB1 alleles: HLA-DRB3*9901 (odds ratio [OR], 1.24; P = 2.49 × 10-9), HLA-DRB5*0101 (OR, 1.29; P = 2.26 × 10-8), HLA-DRB5*9901 (OR, 0.77; P = 1.90 × 10-9), and HLA-DRB3*0301 (OR, 0.63; P = 4.06 × 10-5).
|
30099516 |
2018 |
|
HLA-DRB1
|
Neoplasms
|
0.100 |
GeneticVariation |
BEFREE |
We demonstrated strong association of cervical neoplasia with risk and protective HLA haplotypes that are determined by the amino-acids carried at positions 13 and 71 in pocket 4 of HLA-DRB1 and position 156 in HLA-B.
|
28806749 |
2017 |
|
HLA-DRB1
|
Neoplasms
|
0.100 |
GeneticVariation |
BEFREE |
CD4<sup>+</sup> and HLA-DRB1*1501-restricted TILs isolated from this tumor recognized a single mutation in <i>RBPJ</i> (recombination signal binding protein for immunoglobulin kappa J region).
|
28377481 |
2017 |
|
HLA-DRB1
|
Neoplasms
|
0.100 |
GeneticVariation |
BEFREE |
In contrast, the presence of the DRB1*11:01 allele was negatively associated with CRC tumor as evidenced by the significantly lower AF in CRC patients than that of healthy controls (p = 0.005).
|
25346274 |
2015 |
|
HLA-DRB1
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
We highlight two major aspects of this case: (1) the unusual occurrence of early PTLD involving the cardiac allograft and causing a fatal outcome, (2) the application of an immunological technique for HLA-DRB1 typing to posttransplant paraffin-embedded autopsy material to identify the recipient origin of this early malignancy, thus excluding a possible donor-transmitted neoplasm.
|
23331771 |
2013 |
|
HLA-DRB1
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
The observation that mCMV/PSA(FL) is not effective against TRAMP-PSA is consistent with our previous findings that HLA-DRB1*1501-restricted immune responses to PSA are associated with suppression of effective CD8 T-cell responses to TRAMP-PSA tumors.
|
22576344 |
2012 |
|
HLA-DRB1
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
The study suggests that HLA-DRB1*1501 and HLA-DQB1*0301 may influence the immune response to specific tumor and HPV-encoded epitopes and affect the risk of Kazakh ESCC in XinJiang, China.
|
22588649 |
2012 |
|
HLA-DRB1
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
The present data suggest that HLA-DRB1*01 individuals may have a better ability to efficiently present myeloma-related antigens to immunocompetent cells, which could favor a better immune response against the tumor.
|
18397187 |
2008 |
|
HLA-DRB1
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
We found no correlation between the presence of tumor and DRB1-0301 and -01 alleles.
|
18203322 |
2008 |
|
HLA-DRB1
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
A protective effect of HLA-DRB1*12 for cervical neoplasia was observed, and with stronger associations when subgroup analyses were carried out for patients infected with HPV16 and HPV58.
|
17516530 |
2007 |
|
HLA-DRB1
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
DRB1*03 was associated with node-negative disease and DRB1*08 and 13 with small tumors; DRB1*04 was protective against disease relapse.
|
16573562 |
2006 |
|
HLA-DRB1
|
Neoplasms
|
0.100 |
GeneticVariation |
BEFREE |
Here, we studied three DLBCLs with loss of HLA-DQ expression for mutations in the DQB1 and DQA1 genes and three tumors with loss of HLA-DR expression for mutations in the DRB1 and DRA genes.
|
12756506 |
2003 |
|
HLA-DRB1
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Our investigation was undertaken to analyze the relationship between HLA alleles distribution in patients with melanoma and susceptibility to the tumor, in order to study the possible correlation between HLA class II DQA1, DQB1 and DRB1 genes involved in immune recognition, and melanoma, usually considered a highly immunogenic tumor.
|
9550328 |
1998 |
|
HLA-DRB1
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Our findings support previous studies that have found HLA B7 and DQB1*0302 to be positively associated with cervical neoplasia and are consistent with those that have suggested that DRB1*13 is negatively associated with disease, but do not confirm previous assertions that DRB1*1501-DQB1*0602 increases the risk of cervical disease.
|
9829713 |
1998 |
|
HLA-DRB1
|
Neoplasms
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, patients with the HLA-DRB1 *0101 or *0405 allele tended to be in earlier stages and to have less aggressive tumors than patients with neither of these alleles.
|
9044854 |
1997 |
|
HLA-DRB1
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
In contrast, a negative correlation between DRB1 1301/ 02 alleles and HPV-positive tumors has been observed.
|
8682580 |
1996 |