|
HLA-DRB1
|
Neuromyelitis Optica
|
0.100 |
GeneticVariation |
BEFREE |
CNS-specific ANA were more frequent in MS than in NMOSD patients or HCs (13.5% vs 0% for both comparisons, both p < .05) and were associated with HLA-DRB1*15:01 (p = .0174).
|
31835211 |
2020 |
|
HLA-DRB1
|
Neuromyelitis Optica
|
0.100 |
GeneticVariation |
BEFREE |
Although our study had a small cohort, HLA genotypes were associated with increased susceptibility to NMO for HLA-DRB1*04:05 and *16:02.
|
31090804 |
2019 |
|
HLA-DRB1
|
Neuromyelitis Optica
|
0.100 |
GeneticVariation |
BEFREE |
The HLA-DRB1*03:01 allele was associated with NMO regardless the NMO-IgG status but did not influence the long term disability.
|
28778431 |
2017 |
|
HLA-DRB1
|
Neuromyelitis Optica
|
0.100 |
GeneticVariation |
BEFREE |
HLA haplotype analyses of patients with NMO suggest a positive association with HLA-DRB1* 03:01.
|
27054574 |
2016 |
|
HLA-DRB1
|
Neuromyelitis Optica
|
0.100 |
GeneticVariation |
BEFREE |
The purpose of this study was to assess the relation of the G allele to neuromyelitis optica (NMO)/NMO spectrum disorder (NMOSD) and multiple sclerosis (MS) and the interaction between the G allele and HLA-DRB1 alleles, and to clarify any association of the G allele with clinical features.
|
23549433 |
2013 |
|
HLA-DRB1
|
Neuromyelitis Optica
|
0.100 |
Biomarker |
BEFREE |
Compared with healthy controls, NMO/NMOSD patients showed a significantly lower frequency of DRB1*0901 and significantly higher frequencies of DRB1*1602 and DPB1*0501, which conferred susceptibility to anti-AQP4 antibody positive NMO/NMOSD, but not antibody negative NMO/NMOSD.
|
23038741 |
2013 |
|
HLA-DRB1
|
Neuromyelitis Optica
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of DRB1*13 genotype was higher compared with controls (p=0.002), MS (p=0.001) and NMO (p=0.003) patients.
|
23037550 |
2013 |
|
HLA-DRB1
|
Neuromyelitis Optica
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of HLA-DQB1*0402 allele was increased in NMO (p after Bonferroni correction, cp < 0.035) and the HLA-DRB1*15 and DQB1*06 alleles were increased in MS (cp < 0.0027, cp < 0.01), compared to controls.
|
21908482 |
2012 |
|
HLA-DRB1
|
Neuromyelitis Optica
|
0.100 |
Biomarker |
BEFREE |
In conclusion, comparison of the HLA-DRB1 and DQB1 distribution in NMO and MS in this Afro-Caribbean population shows important differences in the HLA associations among NMO and MS.
|
20861181 |
2011 |
|
HLA-DRB1
|
Neuromyelitis Optica
|
0.100 |
Biomarker |
BEFREE |
The frequency of the DRB1 0901 was lower in NMO patients than in CTLs (P(uncorr)=0.022, OR: 0.194, 95% CI: 0.043-0.876), and DRB1 1602 was higher in NMO patients than in C-MS (P(uncorr)=0.038, OR: 3.491, 95% CI: 1.024-11.896) and CTLs (P(uncorr)=0.051, OR: 2.711, 95% CI: 0.971-7.556).
|
21130504 |
2011 |
|
HLA-DRB1
|
Neuromyelitis Optica
|
0.100 |
GeneticVariation |
BEFREE |
HLA-DRB1*03 allele group was overrepresented in NMO patients compared with healthy controls (p = 0.0401; OR = 3.23, 95%CI: 1.07-9.82).
|
19995845 |
2010 |
|
HLA-DRB1
|
Neuromyelitis Optica
|
0.100 |
GeneticVariation |
BEFREE |
Multiple sclerosis and neuromyelitis optica differ in their associations with DRB1*1501.
|
20591987 |
2010 |
|
HLA-DRB1
|
Neuromyelitis Optica
|
0.100 |
GeneticVariation |
BEFREE |
The distribution of HLA-DRB1 allele enabled to distinguish between NMO-IgG-positive patients and healthy controls (P = 0.01).
|
19299434 |
2009 |