|
HLA-DRB1
|
Polymyalgia Rheumatica
|
0.100 |
Biomarker |
BEFREE |
HLA-DRB1*0101/0102 and *0401 were significantly increased in PMR patients compared with healthy controls.
|
18980958 |
2009 |
|
HLA-DRB1
|
Polymyalgia Rheumatica
|
0.100 |
GeneticVariation |
BEFREE |
Conflicting HLA-DRB1 genotype results have been reported, and recent studies have shown that PMR and GCA have different expression of RANTES, TNFalpha microsatellite, and IL-6 promoter genetic polymorphisms.
|
15079760 |
2004 |
|
HLA-DRB1
|
Polymyalgia Rheumatica
|
0.100 |
GeneticVariation |
LHGDN |
Patients with classic PMR expressed DRB1*07 less frequently (OR, 0.4 [0.1 to 1]; P =.04) and had a higher frequency of the DRYF 28-31 motif (94.8% vs 80.6%; P =.03) than patients with ESR < 40.
|
15305244 |
2004 |
|
HLA-DRB1
|
Polymyalgia Rheumatica
|
0.100 |
AlteredExpression |
BEFREE |
Patients with classic PMR expressed DRB1*07 less frequently (OR, 0.4 [0.1 to 1]; P =.04) and had a higher frequency of the DRYF 28-31 motif (94.8% vs 80.6%; P =.03) than patients with ESR < 40.
|
15305244 |
2004 |
|
HLA-DRB1
|
Polymyalgia Rheumatica
|
0.100 |
Biomarker |
BEFREE |
HLA-DRB1*04 was found in 47% of patients with PMR only and in 54% of patients with GCA, which differed significantly from the 35% found in controls (p = 0.01).
|
12375325 |
2002 |
|
HLA-DRB1
|
Polymyalgia Rheumatica
|
0.100 |
Biomarker |
BEFREE |
These data indicate that (1) HLA associations with RA differ with respect to age at disease onset; and (2) seronegative late onset RA and "isolated" PMR have a similar HLA-DRB1 association and may have an identical etiological basis.
|
11196513 |
2001 |
|
HLA-DRB1
|
Polymyalgia Rheumatica
|
0.100 |
Biomarker |
BEFREE |
In conclusion, in the Mediterranean population studied, HLA-DRB1*01 is associated with RA and PMR whereas HLA-DRB1*04 is associated with RA only.
|
11251689 |
2001 |
|
HLA-DRB1
|
Polymyalgia Rheumatica
|
0.100 |
Biomarker |
BEFREE |
In our patient population, GCA was associated with an increased frequency of HLA-DRB1*04 compared with PMR patients.
|
11407077 |
2001 |
|
HLA-DRB1
|
Polymyalgia Rheumatica
|
0.100 |
GeneticVariation |
BEFREE |
This was found to be independent of the HLA-DRB1*13/*14 association in isolated PMR.
|
10943865 |
2000 |
|
HLA-DRB1
|
Polymyalgia Rheumatica
|
0.100 |
AlteredExpression |
BEFREE |
No significant differences were observed in the frequencies of HLA-DRB1 types and in the expression of HLA-DRB 70-74 shared motif between PMR and controls.
|
10225816 |
1999 |
|
HLA-DRB1
|
Polymyalgia Rheumatica
|
0.100 |
Biomarker |
BEFREE |
The distribution of DRB1*04 subtypes was similar in PMR and GCA, but different from RA and controls.
|
9458210 |
1998 |
|
HLA-DRB1
|
Polymyalgia Rheumatica
|
0.100 |
GeneticVariation |
BEFREE |
Nonsignificant increases in DQA1 and DQB1 phenotype frequencies appeared to reflect known patterns of linkage disequilibrium with the HLA-DRB1 alleles associated with GCA and PMR groups.
|
9818656 |
1998 |
|
HLA-DRB1
|
Polymyalgia Rheumatica
|
0.100 |
GeneticVariation |
BEFREE |
To analyze by molecular typing possible associations of HLA-DRB1 alleles with polymyalgia rheumatica (PMR) compared to controls and patients with rheumatoid arthritis (RA) in Switzerland.
|
9101500 |
1997 |
|
HLA-DRB1
|
Polymyalgia Rheumatica
|
0.100 |
GeneticVariation |
BEFREE |
PMR and GCA share the associated sequence polymorphism encoded by the second hypervariable region (HVR) of the HLA-DRB1 gene.
|
8147928 |
1994 |