Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression BEFREE Here, using cellular and mouse models, we showed that PKCε overexpression acts synergistically with Pten loss to promote NF-κB activation and induce cyclooxygenase-2 (COX-2) expression, phenotypic traits which are also observed in human prostate tumors. 29765153

2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation BEFREE The aim of this study was to evaluate the association of polymorphic genotypes in the cyclooxygenase 2 gene (COX2), which is reported to be overexpressed in prostate tumors, with Taiwan prostate cancer patients. 21273602

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression BEFREE Evidence indicates that COX-2 plays a role in carcinogenesis and that it is overexpressed in prostate tumors. 22023987

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression BEFREE Evidence indicates that COX-2 plays a role in carcinogenesis and that it is over-expressed in prostate tumours. 18974063

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN Evidence indicates that COX-2 plays a role in carcinogenesis and that it is over-expressed in prostate tumours. 18974063

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression LHGDN Translationally regulated C/EBP beta isoform expression upregulates metastatic genes in hormone-independent prostate cancer cells. 18512730

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies. 17999989

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression LHGDN Vasoactive intestinal peptide induces cyclooxygenase-2 expression through nuclear factor-kappaB in human prostate cell lines Differential time-dependent responses in cancer progression. 17434257

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN COX2 genetic variation, NSAIDs, and advanced prostate cancer risk. 17609663

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker CTD_human COX2 genetic variation, NSAIDs, and advanced prostate cancer risk. 17609663

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN Genetic variation in the COX-2 gene and the association with prostate cancer risk. 16506214

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker BEFREE Our findings suggest that blockage of osteopontin and/or COX-2 is a promising therapeutic approach for the inhibition of prostate tumor progression and angiogenesis. 16818637

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker CTD_human Genetic variation in the COX-2 gene and the association with prostate cancer risk. 16506214

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression LHGDN Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate cancer cell line. 15550400

2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Cyclooxygenase-2 expression correlates with local chronic inflammation and tumor neovascularization in human prostate cancer. 15867220

2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker CTD_human Suppression of prostate carcinogenesis by dietary supplementation of celecoxib in transgenic adenocarcinoma of the mouse prostate model. 15126378

2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker CTD_human COX-2 gene promoter haplotypes and prostate cancer risk. 14754878

2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN COX-2 gene promoter haplotypes and prostate cancer risk. 14754878

2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Cyclooxygenase-2, player or spectator in cyclooxygenase-2 inhibitor-induced apoptosis in prostate cancer cells. 11959891

2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression LHGDN Saw palmetto berry extract inhibits cell growth and Cox-2 expression in prostatic cancer cells. 11913955

2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker CTD_human The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. 10753955

2000