Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.040 Biomarker BEFREE Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis. 28818461

2018
Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.040 AlteredExpression BEFREE We confirm that miR-21 expression is increased in epidermal lesions of patients with psoriasis and that this leads to reduced epidermal TIMP-3 (tissue inhibitor of matrix metalloproteinase 3) expression and activation of TACE (tumor necrosis factor-α-converting enzyme)/ADAM17 (a disintegrin and metalloproteinase 17). 24574341

2014
Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.040 Biomarker BEFREE Treatment of K5.Stat3C mice with TNF-α or EGFR inhibitors attenuated the skin lesions, suggesting the roles of TACE substrates in psoriasis. 25384035

2014
Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.040 Biomarker BEFREE It was proposed that TNF-alpha is involved in the pathogenesis of psoriasis, and it is therefore suggested that TACE has important roles in psoriasis. 15888146

2005