|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
AlteredExpression |
BEFREE |
We report that RB-depleted maturing (ARR3<sup>+</sup>) but not immature (ARR3<sup>-</sup>) human cone precursors enter the cell cycle, proliferate, and form retinoblastoma-like lesions with Flexner-Wintersteiner rosettes, then form low or nonproliferative premalignant retinoma-like lesions with fleurettes and p16<sup>INK4A</sup> and p130 expression, and finally form highly proliferative retinoblastoma-like masses.
|
30213853 |
2018 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
AlteredExpression |
BEFREE |
These promoter regions are known to be bound by the E2F family proteins (E2F-1 to E2F-8) and retinoblastoma (RB) family proteins (RB1, p107, and p130), among which E2F-4 and p130 were strongly up-regulated in HSP27-knockdown cells.
|
30166342 |
2018 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
Biomarker |
BEFREE |
Several murine retinoblastoma models have been generated by deleting the genes encoding for retinoblastoma susceptibility protein pRb and one of its family members p107 or p130.
|
27750399 |
2017 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
AlteredExpression |
BEFREE |
Moreover, while forced RB or p130 expression repressed the activity of a luciferase reporter driven by the MYB-E2F element, co-expression of MAZ proteins not only reverted repression, but also activated transcription.
|
28973440 |
2017 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
Biomarker |
BEFREE |
While mutations in the retinoblastoma (RB1) tumor suppressor have been reported in lung cancer, mainly in small cell lung carcinoma, the tumor suppressive role of its relatives p107 and p130 is still a matter of debate.
|
27966456 |
2017 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
Biomarker |
BEFREE |
UL97 strongly interacts with p107 but not Rb or p130.
|
28289097 |
2017 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
Biomarker |
BEFREE |
miR-106a represses the Rb tumor suppressor p130 to regulate cellular proliferation and differentiation in high-grade serous ovarian carcinoma.
|
24045973 |
2013 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
Biomarker |
BEFREE |
Further investigation into the mechanisms of MAGE-A11 function in prostate cancer demonstrated interactions with the retinoblastoma-related protein p107 and Rb tumor suppressor but no interaction with p130 of the Rb family.
|
23853093 |
2013 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
Biomarker |
BEFREE |
A combined deletion of the RB proteins, RB, p107 and p130 (triple-mutant; TM), prevents SATB1-induced G1 arrest, which is restored upon the reintroduction of RB into SATB1-expressing TM fibroblasts.
|
23686316 |
2013 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
Biomarker |
BEFREE |
To investigate the functional relevance of this observation, we inactivated the RB pathway in the liver of adult mice by deleting the three members of the Rb (Rb1) gene family: Rb, p107, and p130.
|
21875955 |
2011 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
Biomarker |
BEFREE |
A second locus for retinoblastoma, RBL2, which encodes the p130 protein, has been shown to contribute to retinoblastoma oncogenesis.
|
20451864 |
2010 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
AlteredExpression |
BEFREE |
We now demonstrate that loss of both RB1 tumor suppressor gene alleles initiates quiescent RB1(-/-) retinomas with low level genomic instability and high expression of the senescence-associated proteins p16(INK4a) and p130.
|
18211953 |
2008 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
Biomarker |
BEFREE |
In this study, we focused on the retinoblastoma-related protein p130 in AD. p130 is a transcriptional regulator that complexes with E2F4/5 in the nucleus and suppresses genes that regulate entry into the cell cycle.
|
17006760 |
2007 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
Biomarker |
BEFREE |
The mammalian Retinoblastoma (RB) family including pRB, p107, and p130 represses E2F target genes through mechanisms that are not fully understood.
|
17531812 |
2007 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
Biomarker |
BEFREE |
Animals lacking Rb and/or its family members p107 and p130 have led scientists to uncover new and exciting roles for this protein family in development as well as tumor suppression.
|
16465443 |
2006 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
Biomarker |
BEFREE |
The best-known cellular targets of the HPV-16 E7 oncoprotein are the retinoblastoma tumor suppressor protein pRB and the related pocket proteins p107 and p130.
|
16061792 |
2005 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
Biomarker |
BEFREE |
The retinoblastoma (pRb), p107, and p130 pocket proteins bind to the E2F transcription factors to control gene expression.
|
15231644 |
2004 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
Biomarker |
BEFREE |
The human cytomegalovirus pp71 protein employs an LXCXD motif to attack the retinoblastoma family members and induce DNA synthesis in quiescent cells. pp71 binds to and induces the degradation of the hypophosphorylated forms of the retinoblastoma protein and its family members p107 and p130 in a proteasome-dependent manner.
|
12612064 |
2003 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
Biomarker |
BEFREE |
Cdx1 expression increased the hypophosphorylation of the retinoblastoma (pRb) and p130 proteins.
|
14508520 |
2003 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
AlteredExpression |
BEFREE |
These observations give evidence that expression of p130 is inversely correlated with higher rates of apoptosis in human retinoblastomas and give an additional example of this regulator's role in cellular differentiation.
|
12454024 |
2002 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
Biomarker |
BEFREE |
The activity of E2F factors is regulated through association with the retinoblastoma tumor suppressor protein (Rb) and the other pocket proteins, p107 and p130.
|
9556498 |
1998 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
Biomarker |
BEFREE |
The retinoblastoma-related protein p130 remained hypophosphorylated in these retinoblastoma-negative cells.
|
8706005 |
1996 |
|
RAB3GAP1
|
Retinoblastoma
|
0.100 |
Biomarker |
BEFREE |
Interactions with the retinoblastoma tumor suppressor, pRb, and related proteins p107 and p130 rely somewhat on CR1 but largely on CR2, which contains a core binding sequence Leu-122-X-Cys-X-Glu.
|
8084002 |
1994 |