|
HLA-DRB1
|
Ankylosing spondylitis
|
0.100 |
Biomarker |
BEFREE |
This study shows that the changes in intestinal microbiome composition seen in AS and RA are at least partially due to effects of HLA-B27 and HLA-DRB1 on the gut microbiome.
|
31038287 |
2019 |
|
HLA-DRB1
|
Ankylosing spondylitis
|
0.100 |
Biomarker |
BEFREE |
Also, HLA-DRB1*04 was present in 62 patients with AS (71.2%) and in 26 with axSpA (15.5%).
|
28013432 |
2017 |
|
HLA-DRB1
|
Ankylosing spondylitis
|
0.100 |
GeneticVariation |
BEFREE |
Using the Korean HLA reference panel, we inferred the classic HLA alleles and amino-acid residues of the six HLA genes (HLA-A, -B, -C, -DPB1, -DQB1, and -DRB1) and MHC single-nucleotide polymorphisms in 3820 Korean subjects, including 654 Korean cases of AS and 3166 controls, who were genotyped by using Immunochip.
|
26613595 |
2015 |
|
HLA-DRB1
|
Ankylosing spondylitis
|
0.100 |
GeneticVariation |
BEFREE |
Our study aims to assess the distribution of HLA-A, -B, -Cw and DRB1 alleles in Moroccan patients with AS and to compare the clinical features of AS and the frequencies of HLA-B27 in patients from Morocco with other series.
|
25626601 |
2015 |
|
HLA-DRB1
|
Ankylosing spondylitis
|
0.100 |
Biomarker |
BEFREE |
Other HLA class I and class II alleles have been implicated in AS susceptibility, the most consistent being HLA-B*40/B60 (B*40:01) but also B14, B15, A*0201, DRB1*04:04, and certain DPA1 and DPB1 alleles.
|
24838411 |
2014 |
|
HLA-DRB1
|
Ankylosing spondylitis
|
0.100 |
Biomarker |
BEFREE |
A*02/B27/C*02/DRB1*01/DQB1*05 [P<0.0001; odds ratio (OR) = 39.06; 95% confidence interval (CI) (2.34-651)] is the only haplotype that seems to confer susceptibility to AS.
|
24498993 |
2013 |
|
HLA-DRB1
|
Ankylosing spondylitis
|
0.100 |
Biomarker |
BEFREE |
However, DRB1*13 had a negative association with AS (P = 0.01, OR = 0.4, 0.2 < CI < 0.8).
|
19655145 |
2010 |
|
HLA-DRB1
|
Ankylosing spondylitis
|
0.100 |
GeneticVariation |
BEFREE |
His HLA type included both the B27 allele conferring susceptibility to ankylosing spondylitis and the B35, DRB1 11, and DQB1 03 described as associated with systemic sclerosis.
|
19372061 |
2009 |
|
HLA-DRB1
|
Ankylosing spondylitis
|
0.100 |
Biomarker |
BEFREE |
The accuracy of the prognosis of radiographic severity in AS is improved by knowing the age at disease onset, sex, smoking history, and the presence of HLA-B*4100, DRB1*0804, DQA1*0401, DQB1*0603, DRB1*0801, and DPB1*0202 alleles.
|
19565552 |
2009 |
|
HLA-DRB1
|
Ankylosing spondylitis
|
0.100 |
GeneticVariation |
BEFREE |
673 individuals from 261 families with ankylosing spondylitis were genotyped for HLA-DRB1 alleles and HLA-B27 heterozygosity/homozygosity.
|
16249228 |
2006 |
|
HLA-DRB1
|
Ankylosing spondylitis
|
0.100 |
Biomarker |
BEFREE |
Predictors of failure to attain disease remission included the following: ankylosing spondylitis (AS) in a first-degree relative, the presence of HLA-DRB1*08, and ankle arthritis within the first 6 months.
|
17075863 |
2006 |
|
HLA-DRB1
|
Ankylosing spondylitis
|
0.100 |
GeneticVariation |
BEFREE |
Twenty-three patients with AS and 39 controls were typed for DRB1 alleles.
|
12021150 |
2002 |
|
HLA-DRB1
|
Ankylosing spondylitis
|
0.100 |
GeneticVariation |
BEFREE |
The results of this study suggest that DRB1*01 antigens might be involved in the development of sporadic forms of ankylosing spondylitis in HLA-B27 negative individuals in the studied area.
|
12477229 |
2002 |
|
HLA-DRB1
|
Ankylosing spondylitis
|
0.100 |
Biomarker |
BEFREE |
We studied the relationship between DRB1*08 and disease phenotype in additional populations of individuals with AS.
|
9150079 |
1997 |