Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5308
Gene Symbol: PITX2
PITX2
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.370 Biomarker BEFREE AF and stroke are related and ZNF566, PDZK1IP1, ZFHX3, and PITX2 genes are significantly associated with novel biomarkers involved in AF-related stroke. 30760287

2019

Entrez Id: 5308
Gene Symbol: PITX2
PITX2
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.370 Biomarker CTD_human Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. 29531354

2018

Entrez Id: 5308
Gene Symbol: PITX2
PITX2
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.370 Biomarker BEFREE Our results also supported robust associations with ischaemic stroke for four other loci that have been reported in previous studies, including PITX2 (first stage OR 1·39, 1·29-1·49, p=3·26 × 10<sup>-19</sup>; joint OR 1·37, 1·30-1·45, p=2·79 × 10<sup>-32</sup>) and ZFHX3 (first stage OR 1·19, 1·11-1·27, p=2·93 × 10<sup>-7</sup>; joint OR 1·17, 1·11-1·23, p=2·29 × 10<sup>-10</sup>) for cardioembolic stroke, and HDAC9 (first stage OR 1·29, 1·18-1·42, p=3·50 × 10<sup>-8</sup>; joint OR 1·24, 1·15-1·33, p=4·52 × 10<sup>-9</sup>) for large artery atherosclerosis stroke. 26708676

2016

Entrez Id: 5308
Gene Symbol: PITX2
PITX2
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.370 GeneticVariation BEFREE In our study we are focusing on a possible correlation between detection of atrial fibrillation by an implantable ECG recorder, and PITX2 and/or ZFHX3 gene mutations in cryptogenic stroke/TIA patients. 26631084

2015

Entrez Id: 5308
Gene Symbol: PITX2
PITX2
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.370 GeneticVariation BEFREE Four of 7 previously reported ischemic stroke loci (PITX2, HDAC9, CDKN2A/CDKN2B, and ZFHX3) were nominally associated (P<0.05) with stroke in COMPASS. 26089329

2015

Entrez Id: 5308
Gene Symbol: PITX2
PITX2
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.370 Biomarker BEFREE We verified previous associations for cardioembolic stroke near PITX2 (p=2·8×10(-16)) and ZFHX3 (p=2·28×10(-8)), and for large-vessel stroke at a 9p21 locus (p=3·32×10(-5)) and HDAC9 (p=2·03×10(-12)). 23041239

2012

Entrez Id: 5308
Gene Symbol: PITX2
PITX2
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.370 GeneticVariation BEFREE We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. 22306652

2012

Entrez Id: 5308
Gene Symbol: PITX2
PITX2
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.370 GeneticVariation BEFREE Each of these underlying pathologies may have a specific genetic architecture.Previous genome-wide association studies (GWAS) showed association of variants near PITX2 and ZFHX3 with atrial fibrillation and stroke. 22776031

2012