Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.100 AlteredExpression BEFREE We therefore believe that before clinically confirming an AA diagnosis, these parameters may be used as diagnostic tools in addition to CBC parameters, CRP levels and radiological imaging studies. 30871739

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.100 AlteredExpression BEFREE WBC and CRP levels of the AA and PA groups were significantly higher compared to the group with non-specific abdominal pain. 30723978

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.100 GeneticVariation BEFREE The combination of low values of pro-ADM and CRP can help to select children with low risk of AA. 30287129

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.100 AlteredExpression BEFREE Clinical findings can differentiate AA and ARCD before imaging studies; nausea/vomiting and anorexia suggest AA, and longer onset-to-visit interval, RLQ pain, previous diverticulitis, and CRP level > 3.0 mg/dL suggest ARCD. 31363467

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.100 GeneticVariation BEFREE In the work-up of children with suspected acute appendicitis, most surgeons rely on full blood count (92%), C-reactive protein (82%), and abdominal ultrasonography (76%), but rarely on computed tomography scans or magnetic resonance imaging. 30112745

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.100 AlteredExpression BEFREE ROC curve analysis revealed white blood cell count, absolute neutrophils count (ANC), C-reactive protein, total-bilirubin and direct-bilirubin levels as significant factors for diagnosis of AA. 29527857

2018

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.100 Biomarker BEFREE CRP and white blood cell count (WBC) were significantly higher in the group with confirmed AA compared to the control group (44.7 <i>vs</i>.6.6, and 13.6 ± 3.9 <i>vs</i>.9.0 ± 3.4, respectively; P < 0.001). 30429680

2018

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.100 Biomarker BEFREE Acute appendicitis remains diagnostically challenging and cannot be excluded on the basis of normal CRP and WCC. 27625212

2018

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.100 Biomarker BEFREE Moreover, blood was drawn from patients with acute appendicitis (9♀,11♂) and healthy volunteers (10♀,10♂) for determination of CRP, blood count and phosphatidylserine. 28214863

2017

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.100 AlteredExpression BEFREE The aim of the present study was to compare the pediatric appendicitis score (PAS), the Alvarado score (AS), white blood cell count (WBC), absolute neutrophil count (ANC), C-reactive protein (CRP) level, procalcitonin level, and ultrasound (US) data, with the appendectomy decisions of pediatric surgeons diagnosing acute appendicitis (AA) in a real-life setting; this was a top-level, high-volume pediatric emergency department (PED) in a developing country. 27331578

2017

Entrez Id: 213
Gene Symbol: ALB
ALB
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.020 Biomarker BEFREE The value of ischemia-modified albumin and oxidative stress markers in the diagnosis of acute appendicitis in adults. 30871739

2019

Entrez Id: 213
Gene Symbol: ALB
ALB
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.020 Biomarker BEFREE Ischemia-modified albumin as a predictor of the severity of acute appendicitis. 27769665

2017

Entrez Id: 4810
Gene Symbol: NHS
NHS
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.010 Biomarker BEFREE What is the Operative Cost of Managing Acute Appendicitis in the NHS: The Impact of Stump Technique and Perioperative Imaging. 31773223

2020

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.010 Biomarker BEFREE IP-10, MIP-1α and IL-10 showed potential in assessment of AA in children. 31615548

2019

Entrez Id: 4669
Gene Symbol: NAGLU
NAGLU
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.010 Biomarker BEFREE This study evaluated the diagnostic performance of a new clinical approach based on decision tree (DT) analysis in adult patients with equivocal computed tomography (CT) findings of acute appendicitis (AA) compared with previous scoring systems.This retrospective study of 244 adult patients with equivocal CT findings included appendicitis (AG, n = 80) and non-appendicitis (NAG, n = 164) groups. 31577737

2019

Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.010 Biomarker BEFREE IP-10, MIP-1α and IL-10 showed potential in assessment of AA in children. 31615548

2019

Entrez Id: 51594
Gene Symbol: NBAS
NBAS
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.010 Biomarker BEFREE This study evaluated the diagnostic performance of a new clinical approach based on decision tree (DT) analysis in adult patients with equivocal computed tomography (CT) findings of acute appendicitis (AA) compared with previous scoring systems.This retrospective study of 244 adult patients with equivocal CT findings included appendicitis (AG, n = 80) and non-appendicitis (NAG, n = 164) groups. 31577737

2019

Entrez Id: 5806
Gene Symbol: PTX3
PTX3
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.010 Biomarker BEFREE PTX3 can be used as an aid in the diagnosis of acute appendicitis. 29020470

2019

Entrez Id: 3578
Gene Symbol: IL9
IL9
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.010 Biomarker BEFREE Here, we propose the concept of appendicular lavage and use it to study the levels of the Th2 cytokines IL-4, IL-5, and IL-9 in patients with a clinical diagnosis of acute appendicitis. 31772507

2019

Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.010 AlteredExpression BEFREE Additionally, serum concentrations of Zn, CP, CZr, or SOD1 activity varied in different pathological types of AA. 30771140

2019

Entrez Id: 6348
Gene Symbol: CCL3
CCL3
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.010 Biomarker BEFREE IP-10, MIP-1α and IL-10 showed potential in assessment of AA in children. 31615548

2019

Entrez Id: 5308
Gene Symbol: PITX2
PITX2
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.010 AlteredExpression BEFREE Genetic association and differential expression of PITX2 with acute appendicitis. 30392061

2019

Entrez Id: 6288
Gene Symbol: SAA1
SAA1
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.010 AlteredExpression BEFREE Plasma levels of IL-6, CRP, MCP-1, PCT, and SAA were significantly different in children with AA compared to those with NAAP (<i>p</i> < 0.001). 30918467

2019

Entrez Id: 6332
Gene Symbol: SCN7A
SCN7A
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.010 Biomarker BEFREE This study evaluated the diagnostic performance of a new clinical approach based on decision tree (DT) analysis in adult patients with equivocal computed tomography (CT) findings of acute appendicitis (AA) compared with previous scoring systems.This retrospective study of 244 adult patients with equivocal CT findings included appendicitis (AG, n = 80) and non-appendicitis (NAG, n = 164) groups. 31577737

2019

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.010 Biomarker BEFREE Here, we propose the concept of appendicular lavage and use it to study the levels of the Th2 cytokines IL-4, IL-5, and IL-9 in patients with a clinical diagnosis of acute appendicitis. 31772507

2019