Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1387
Gene Symbol: CREBBP
CREBBP
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.330 Biomarker BEFREE In contrast to CREBBP wild-type SCLC cells, CREBBP-mutated SCLC cells showed significantly lower IC<sub>50</sub> values after treatment with HDACi. 31068675

2019
Entrez Id: 1387
Gene Symbol: CREBBP
CREBBP
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.330 Biomarker BEFREE In addition, a subset of <i>Rb1/Trp53/Crebbp</i>-deficient SCLC exhibited exceptional responses to Pracinostat <i>in vivo</i> Thus, CREBBP acts as a potent tumor suppressor in SCLC, and inactivation of CREBBP enhances responses to a targeted therapy.<b>Significance:</b> Our findings demonstrate that CREBBP loss in SCLC reduces histone acetylation and transcription of cellular adhesion genes, while driving tumorigenesis. 30181244

2018
Entrez Id: 1387
Gene Symbol: CREBBP
CREBBP
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.330 GeneticVariation BEFREE While both components showed TMPRSS2:ERG fusions, the SCC component exclusively harbored complete TP53 inactivation (frameshift variant and copy loss) and two CREBBP mutations. 25735316

2015
Entrez Id: 1387
Gene Symbol: CREBBP
CREBBP
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.330 Biomarker CTD_human Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. 22941188

2012