Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3248
Gene Symbol: HPGD
HPGD
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.060 Biomarker BEFREE These findings provide evidence that 15-PGDH inhibition enhances KRAS-driven tumor progression via ATRA depletion in the pancreas. 30250298

2019
Entrez Id: 3248
Gene Symbol: HPGD
HPGD
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.060 Biomarker BEFREE The reduced 15-PGDH may result in PGE2 accumulation which sustains carcinogenesis and tumor progression. 29101039

2018
Entrez Id: 3248
Gene Symbol: HPGD
HPGD
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.060 AlteredExpression BEFREE These results show a key 15-PGDH/15-keto-PGE2-mediated activation of PPARγ and p21(WAF1/Cip1) signaling cascade that regulates hepatocarcinogenesis and tumor progression. 23542179

2014
Entrez Id: 3248
Gene Symbol: HPGD
HPGD
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.060 AlteredExpression BEFREE The overexpression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) has been proved to inhibit tumor growth and metastasis through degradation of prostaglandin E2 (PGE2), which is often overexpressed in various cancers and accelerates tumor progression. 23385883

2013
Entrez Id: 3248
Gene Symbol: HPGD
HPGD
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.060 AlteredExpression BEFREE 15-PGDH is down-regulated in gastric cancer, which could potentially lead to accelerated tumor progression. 19584167

2009
Entrez Id: 3248
Gene Symbol: HPGD
HPGD
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.060 Biomarker BEFREE These models thus delineate the in vivo significance of 15-PGDH-mediated negative regulation of the COX-2 pathway and moreover reveal the particular importance of 15-PGDH in opposing the neoplastic progression of colonic aberrant crypt foci. 16880406

2006