Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE WT p53 is critical for tumor suppression, whereas mutant p53 promotes tumor progression. 29073078

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression. 28947497

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Crosstalk between transforming growth factor beta (TGF-β) signaling and p53 has a critical role in cancer progression. 27893708

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Patients with XPF CC (hazard ratio (HR) 2.45, P = 0.002; HR 3.77, P = 0.005) and XPF CC + TP53 ArgArg (HR 2.67, P = 0.009; HR 4.04, P = 0.03) genotypes had more chance to present tumor progression in univariate and multivariate analyses, whereas patients with XPF CC (HR 2.78, P = 0.009) and XPF CC + TP53 ArgArg (HR 3.84, P = 0.01) genotypes were under greater risk of progressing to death in univariate analysis, compared with those with the remaining genotypes. 26427666

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression. 26032560

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE EGFR and p53 are molecular markers which play important role in tumor progression and development. 26177827

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE PIK3CA, SMAD4, and TP53 are most often involved in clonal divergence, providing potential targets that may help guide the clinical management of tumor progression or metastases. 25695693

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Interestingly, the inactivation of p53 after senescence resulted in reentry into the cell cycle and rapid tumor progression. 26598601

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Clinically relevant, low concentrations of doxorubicin synergize in vitro and in vivo with DCA to further enhance p53 activation and to block tumor progression. 26231043

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Multiple evidences implicate that over-expression of MDM4 is associated with tumor progression and poor prognosis which can be reversed by knockdown of MDM4 expression or restoration of p53 function, and support the rationale for the design of future MDM4-specific therapeutics. 26567881

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE TSH overcomes Braf(V600E)-induced senescence to promote tumor progression via downregulation of p53 expression in papillary thyroid cancer. 26477313

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE On the contrary, p53 loss led to increased apoptosis that had to be overcome for tumor progression. 24469052

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Altered p53 regulation of miR-148b and p55PIK contributes to tumor progression in colorectal cancer. 24632606

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Several p53 mutant proteins acquire the capability to promote cancer progression and metastasis, a phenomenon defined as Gain of Oncogenic Function (GOF). 24681808

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Emerging from the shade of p53 mutants: N-terminally truncated variants of the p53 family in EMT signaling and cancer progression. 25270260

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The 14-3-3ζ-driven contextual changes of Smad partners from p53 to Gli2 may serve as biomarkers and therapeutic targets of TGF-β-mediated cancer progression. 25670079

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE These findings are relevant to human basal-like tumor progression in vivo, since miR-146a is highly expressed in p53 mutant basal-like breast cancers. 25123132

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE However, the presence of p53 mutations in skin premalignant lesions suggests that these represent early events during tumor progression and additional alterations may be required for SCC development. 25639555

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE These results uncover a new mechanism of p53 inactivation providing an interesting novel molecular link between metabolic diseases such as diabetes or obesity and tumor progression and resistance to therapies. 25260780

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Moreover, by two-dimensional gel electrophoresis and mass spectrometry we discovered that the aggregated p53 may function uniquely by interacting with proteins that are critical for cancer cell survival and tumor progression. 25263447

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Many cancers express mutant p53 proteins that have lost wild-type tumor suppressor activity and, in many cases, have acquired oncogenic functions that can contribute to tumor progression. 25417702

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The p53 and NFκB sequence-specific transcription factors play crucial roles in cell proliferation and survival with critical, even if typically opposite, effects on cancer progression. 25401416

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE This study provides the first time evidence that RRM2B is transcriptionally and functionally regulated independent of p53 pathway by FOXO3, and it establishes that FOXO3 and RRM2B could be used as predictive biomarkers for cancer progression. 24947616

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE These results suggest that stroma-derived p53 plays a pivotal role in epithelial cancer progression and that TSPAN12 and CXCL6 are potential targets for lung cancer therapy. 25512506

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Oncogenic stimuli trigger the DNA damage response (DDR) and induction of the alternative reading frame (ARF) tumor suppressor, both of which can activate the p53 pathway and provide intrinsic barriers to tumor progression. 23852374

2014