Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0238033
Disease: Carcinoma of Male Breast
Carcinoma of Male Breast 		0.060 GeneticVariation BEFREE Inherited mutations in BRCA1, BRCA2 and PALB2 genes, as well as common polymorphisms, play a role in male breast cancer genetic predisposition. 31336362

2019
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0238033
Disease: Carcinoma of Male Breast
Carcinoma of Male Breast 		0.060 GeneticVariation BEFREE Targeted PALB2 sequencing detected the c.1984A>T nonsense mutation in 1 of the 48 BRCA1/2 mutation-negative MBC cases. 27648926

2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0238033
Disease: Carcinoma of Male Breast
Carcinoma of Male Breast 		0.060 GeneticVariation BEFREE Pathogenic variants in BRCA2 [odds ratio (OR) = 13.9; p = 1.92 × 10<sup>-16</sup>], CHEK2 (OR = 3.7; p = 6.24 × 10<sup>-24</sup>), and PALB2 (OR = 6.6, p = 0.01) were associated with significantly increased risks of MBC. 28008555

2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0238033
Disease: Carcinoma of Male Breast
Carcinoma of Male Breast 		0.060 Biomarker BEFREE Our findings indicate that PALB2 could be added to the list of breast cancer susceptibility genes also in families with MBC cases. 25529982

2015
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0238033
Disease: Carcinoma of Male Breast
Carcinoma of Male Breast 		0.060 GeneticVariation BEFREE Thus, our study does not support an enrichment of PALB2 germline mutations in the subset of breast cancer families with male breast cancer cases. 22052327

2012
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0238033
Disease: Carcinoma of Male Breast
Carcinoma of Male Breast 		0.060 GeneticVariation BEFREE Our objectives are to determine the frequency of pathogenic mutations in BRCA2 and PALB2 in MBC cases and to investigate the correlations between mutation status and cancer phenotypes. 20927582

2011