×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
Biomarker
BEFREE
The combination of INC280/buparlisib resulted in no clear activity in patients with recurrent PTEN -deficient glioblastoma .
31776899 2020
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
Biomarker
BEFREE
Involvement of Phosphatase and Tensin Homolog in Cyclin-Dependent Kinase 4/6 Inhibitor-Induced Blockade of Glioblastoma .
31787897 2019
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
AlteredExpression
BEFREE
Analyses of human glioblastoma specimens reveals that PGK1 Y324 phosphorylation levels inversely correlate with PTEN expression status and are positively associated with poor prognosis in glioblastoma patients.
31492635 2019
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
Biomarker
BEFREE
The effect of miR-579 on the PI3K/AKT pathway in human glioblastoma PTEN mutant cell lines.
31243804 2019
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
Biomarker
BEFREE
In addition, miR-29a robustly promotes invasion in PTEN -deficient glioblastoma cells by repressing translation of the Sox4 transcription factor, and this upregulates the invasion-promoting protein, HIC5.
30683134 2019
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
GeneticVariation
BEFREE
Glioblastoma harbors frequent alterations in receptor tyrosine kinases, phosphatidylinositol‑3 kinase (PI3K) and phosphatase and tensin homolog (PTEN) that dysregulate phospholipid signaling driven tumor proliferation and therapeutic resistance.30942445 2019
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
GeneticVariation
BEFREE
However, neither PTEN nor EGFR mutation, which is frequently present in glioblastoma , was detected.
30496796 2019
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
GeneticVariation
BEFREE
This study aimed to establish a radiomic signature to predict PTEN mutation status in patients with glioblastoma , and to investigate the genetic background behind this radiomic signature.
31218383 2019
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
Biomarker
BEFREE
Both PTEN -deficient (U-251) and PTEN -containing (LN229) glioblastoma cells showed a decrease in cell migration velocity in response to SKIP downregulation.
30695232 2019
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
AlteredExpression
BEFREE
To identify transcriptomic profiles associated with a hyperactivated PI3K pathway, RNA-sequencing analysis was performed in a glioblastoma cell line stably expressing PTEN .
29729901 2018
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
Biomarker
BEFREE
NQO1 Is Regulated by PTEN in Glioblastoma , Mediating Cell Proliferation and Oxidative Stress.
30595797 2018
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
Biomarker
BEFREE
We generated 3 PARPi-resistant PTEN -deficient glioblastoma U251 variants separately with olaparib (U251/OP), talazoparib (U251/TP) and simmiparib (U251/SP).
29274141 2018
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
Biomarker
BEFREE
Additive effects of the combined expression of soluble forms of GAS1 and PTEN inhibiting glioblastoma growth.
29941984 2018
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
Biomarker
BEFREE
Mitochondrial energy metabolism and signalling in human glioblastoma cell lines with different PTEN gene status.
29209894 2018
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
Biomarker
BEFREE
Publisher Correction: PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3.
29799523 2018
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
Biomarker
BEFREE
These observations demonstrate that NHEJ contributes to p53-mediated glioblastoma suppression, and reveal a crucial role for PTEN in the early DNA damage signalling cascade, the inhibition of which promotes tumorigenicity and drug-resistant survival.
28094268 2017
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
GeneticVariation
BEFREE
Correction of PTEN mutations in glioblastoma cell lines via AAV-mediated gene editing.
28464039 2017
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
AlteredExpression
BEFREE
Corrigendum: Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.
28805210 2017
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
GeneticVariation
BEFREE
Discordant patterns of TP53 and PTEN mutations suggested that the second tumor was not a recurrence but an independently developed glioblastoma .
28922847 2017
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
Biomarker
BEFREE
The E3 ubiquitin ligase CHIP/miR-92b/PTEN regulatory network contributes to tumorigenesis of glioblastoma .
28337377 2017
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
Biomarker
BEFREE
By analysing PTEN in malignant glioblastoma primary cells derived from 16 of our patients, we report mutations that block localization of PTEN at the plasma membrane and nucleus without affecting lipid phosphatase activity.
28263967 2017
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
Biomarker
BEFREE
Hif-1α also positively correlates with H19 in human glioblastoma samples depending on PTEN status.
28327666 2017
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
Biomarker
BEFREE
Combining PARP inhibitors with radiation therapy for the treatment of glioblastoma : Is PTEN predictive of response?
27655368 2017
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
Biomarker
BEFREE
PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3.28497778 2017
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Childhood Glioblastoma
0.100
Biomarker
BEFREE
We analyzed the therapeutic potential of S6K1 inhibitors in PTEN -deficient T cell leukemia and glioblastoma .
28249155 2017