Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.240 Biomarker BEFREE Moreover, we show that heterozygous conditional deletion of ADAM10 or delivery of a competitive TAT-Pro-ADAM10709-729 peptide in R6/2 mice prevents N-CAD proteolysis and ameliorates cognitive deficits in the mice. 31063986

2019
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.240 Biomarker BEFREE AD-10 was associated with a more widespread cognitive deficit across multiple domains, in contrast to Age-10. 29858162

2018
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.240 Biomarker RGD Sleep deprivation accelerates the progression of alzheimer's disease by influencing Aβ-related metabolism. 28455102

2017
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.240 AlteredExpression BEFREE These findings provide new insights into the sources and mechanisms by which hLf inhibits the cognitive decline that occurs in AD via activation of ADAM10 expression in an ERK1/2-CREB and HIF-1α-dependent manner. 28079060

2017
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.240 AlteredExpression BEFREE This provides further evidence that ADAM10 in vivo by its enzymatic activity is able to counteract cognitive deficits. 19221420

2009