|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
Biomarker |
BEFREE |
Human leukocyte antigen (HLA)-DRB1*03 is over-represented in LS, and is associated with a good prognosis, whereas HLA-DRB1*15-positive patients have a more chronic course of sarcoidosis.
|
30585624 |
2019 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
Biomarker |
BEFREE |
Vimentin has been implicated in pulmonary sarcoidosis as a T-cell autoantigen, particularly in the context of <i>HLA-DRB1*03</i>, the Vα2.3/Vβ22 T-cell receptor (TCR), and Löfgren's syndrome.
|
30038611 |
2018 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
Biomarker |
BEFREE |
Bronchoalveolar lavage fluid cells from four HLA-DRB1*03<sup>+</sup> LS and four HLA-DRB1*03<sup>-</sup> non-LS patients were analyzed by mass cytometry, using a panel of 33 unique markers.
|
28955342 |
2017 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
Biomarker |
BEFREE |
Previous work has indicated that HLA-DRB1*03:01<sup>+</sup> (DR3<sup>+</sup>) patients diagnosed with the acute form of the disease, Löfgren's syndrome (LS), have an accumulation of CD4<sup>+</sup> T cells bearing TCRs using TRAV12-1 (formerly AV2S3).
|
28827283 |
2017 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
GeneticVariation |
BEFREE |
Löfgren's syndrome has been linked to patients with the DRB1*03 allele, and non-resolving disease has been associated with the DRB1*07, DRB1*14 and DRB1*15 alleles.
|
23911360 |
2013 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
Biomarker |
BEFREE |
HLA-DRB1*03, besides the association with Löfgren syndrome was significantly related with disease resolution.
|
23017494 |
2012 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
AlteredExpression |
BEFREE |
The finding of a new genetic association between Löfgren's syndrome and MHC2TA gene polymorphisms, which seems independent of HLA-DRB1*03 and relates to the expression of MHC class II molecules, strongly supports the idea that Löfgren's syndrome is a separate disease entity.
|
20230522 |
2010 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
GeneticVariation |
BEFREE |
Löfgren's syndrome is a common sarcoidosis phenotype in the Dutch and is strongly associated with the DRB1*0301 allele.
|
20685690 |
2010 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
Biomarker |
BEFREE |
We clinically characterized and HLA-DRB1 typed 301 patients with Löfgren's syndrome.
|
18996998 |
2009 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
GeneticVariation |
BEFREE |
Indeed, low IFN gamma producers genotype (3/3 homozygotes) and HLA DRB1*03 constitute risk factors of Lofgren syndrome in a combined fashion.
|
18976443 |
2008 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
GeneticVariation |
BEFREE |
This study confirms that CCR2 haplotype 2 and HLA-DRB1*0301 are independent genetic risk factors for Löfgren's syndrome.
|
18513341 |
2008 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
GeneticVariation |
BEFREE |
Developments in genetics have demonstrated that 99% of the human leukocyte antigen DRB1*0301/DQB1*0201-positive patients with Löfgren's syndrome show a spontaneous remission, in contrast to only 55% of the human leukocyte antigen DRB1*0301/DQB1*0201-negative patients.
|
18664976 |
2008 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
GeneticVariation |
BEFREE |
However, after exclusion of patients presenting with Löfgren's syndrome and after adjusting for HLA-DRB1 alleles, the association between BTNL2 rs2076530 A and disease disappeared (P = 0.23).
|
17661910 |
2007 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
GeneticVariation |
BEFREE |
In this regard, the association between Löfgren's syndrome and the extended HLA-DRB1*0301/DQB1*0201 haplotype is probably the most extensively reproduced.
|
17560301 |
2007 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
Biomarker |
BEFREE |
Furthermore, HLA-DRB1*0301/DQB1*0201 has been associated with good prognosis in Löfgren's syndrome.
|
17330189 |
2007 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
GeneticVariation |
BEFREE |
However, this HSP(+2763)-G allele was present with either DRB1*03 or HSP(+2437)-C within the same haplotypes in the patients and this might explain the observed prevalence of DRB1*03, HSP(+2437)-C and (+2763)-G in patients with LS.
|
16611259 |
2006 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
Biomarker |
BEFREE |
Our results revealed that DRB1*03/*11, DQB1*02, DQA*0501 in Stage I of SA with Löfgren's syndrome (Ls) and DRB1*15, DQA1*0102/*0103 in Stage II of SA were more common, whereas DQA1*0102 (Ls) and DRB1*16/*04/*08, DQB1*03/*04/*05/*06, DQA1*0301 (Ls, Stage II) were less common than in the controls.
|
18038917 |
2006 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
GeneticVariation |
BEFREE |
The data suggest that the LTAlpha and HLA-DRB1 genes themselves or a gene located nearby contributes to the susceptibility to sarcoidosis and that TNF-308*A, LTA+252*G and HLA-DRB1*03 alleles are associated (directly or via linkage with unknown causative locus) with LS as a specific manifestation of the disease.
|
15713215 |
2005 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
Biomarker |
BEFREE |
As expected, DRB1*03 prevailed in LS cases (9/14 versus 7/29, P = 0.014 LS versus non-LS cases and 9/14 versus 35/162, OD = 6.20, P = 0.001, LS patients versus controls).
|
15019280 |
2004 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
GeneticVariation |
BEFREE |
The association between CCR2-haplotype 2 carriage frequency and Löfgren's syndrome (odds ratio, 4.4; p < 0.0001) remained significant after adjustment for human leukocyte antigen haplotype DRB1*0301-DQB1*0201 (odds ratio, 11.5; p < 0.0001) and female sex (odds ratio, 3.2; p = 0.003), two known risk factors for Löfgren's syndrome.
|
12882757 |
2003 |
|
HLA-DRB1
|
Lofgrens syndrome
|
0.100 |
GeneticVariation |
BEFREE |
An analysis of DRB1 and DRB3 associations in variants of sarcoidosis revealed that DRB1*03 and DRB3*0101 were associated with Löfgren's syndrome in a combined association fashion.
|
11169267 |
2001 |