|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, an interaction between smoking and the HLA-DRB1 shared epitope (SE) has been demonstrated to be a risk factor for seropositive RA.
|
30742363 |
2019 |
|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
The RF-positive polyarthritis association at HLA-DRB1 amino acid at position 13 mirrors the association in adult seropositive rheumatoid arthritis (RA).
|
27998952 |
2017 |
|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
Consistent with the findings in European and East Asian populations, the association of RA with HLA-DRB1 amino acid position 11 conferred the strongest effect (P = 4.8 × 10<sup>-16</sup> ), and a weighted genetic risk score of previously associated RA loci was found to be associated with RA (P = 3.41 × 10<sup>-5</sup> ) and with seropositive RA (P = 1.48 × 10<sup>-6</sup> ) in this population.
|
28118524 |
2017 |
|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
Using existing genome-wide SNP data in 5,018 individuals with seropositive rheumatoid arthritis (cases) and 14,974 unaffected controls, we imputed and tested classical alleles and amino acid polymorphisms in HLA-A, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1 and HLA-DRB1, as well as 3,117 SNPs across the MHC.
|
22286218 |
2012 |
|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
Interaction between RANKL and HLA-DRB1 genotypes may contribute to younger age at onset of seropositive rheumatoid arthritis in an inception cohort.
|
15476205 |
2004 |
|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
The relatively rare DRB1*10 had an unexpected association with seropositive RA, being present in 1.7% of seropositive RA patients and 0.7% of controls, and also showed a trend toward association with greater disease severity.
|
12355479 |
2002 |
|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
Biomarker |
BEFREE |
Stratification of late onset RA cases by rheumatoid factor status revealed that DRB1*01 was only increased in seropositive RA cases.
|
11196513 |
2001 |
|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
Analyses also suggested that shared epitope DRB1 genotype significantly influenced the occurrence of seropositive RA.
|
10332964 |
1999 |
|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
In this population, DRB1*0901 may promote while DRB1*08 alleles may protect against a juvenile onset of RA specifically.
|
9858424 |
1998 |
|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
Since the associations between DRB1 genes and susceptibility to RA are incomplete, in this study we examined the CA repeat polymorphic marker DQCAR, located between DQA1 and DQB1 genes, alleles in 98 adult patients with seropositive RA and 100 normal healthy controls.
|
9694353 |
1998 |
|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
However, since these three donors are all HLA DRB1*0401, it is unlikely that this HLA type, associated with seropositive RA, accounts for the individual differences.
|
9464528 |
1998 |
|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
We determined HLA-DRB1 alleles in 322 patients with seropositive RA by polymerase chain reaction and allele specific oligonucleotide probe techniques.
|
9415632 |
1997 |
|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
Biomarker |
BEFREE |
The impact of HLA-DRB1*0405 on disease severity in Korean patients with seropositive rheumatoid arthritis.
|
9159536 |
1997 |
|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
The HLA-DRB1*0401/0404 genotype is particularly associated with severe, erosive and seropositive RA.
|
7552063 |
1995 |
|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
DRB1*0404 (encoding the Dw14.1 variant of DR4) was increased to some extent in all examined RA subsets.
|
7983637 |
1994 |
|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
The second exon of the DRB1 gene encoding for the first domain of the HLA-DR beta 1-chain was sequenced in 16 patients (10 DR4/DR1 positive, 6 DR4/DR1 negative) with seropositive rheumatoid arthritis (RA).
|
8494871 |
1993 |
|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
One of the genetic components of seropositive rheumatoid arthritis has been mapped to a short sequence stretch in the third hypervariable region of the HLA-DRB1 gene.
|
8452767 |
1993 |
|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
GeneticVariation |
BEFREE |
Seropositive rheumatoid arthritis is genetically linked to a group of HLA-DRB1 alleles sharing a sequence motif within the third hypervariable region.
|
1602009 |
1992 |
|
HLA-DRB1
|
Seropositive rheumatoid arthritis
|
0.100 |
Biomarker |
BEFREE |
Analysis of HLA DRB1 and DQB1 Bam HI RFLPs revealed four DRB1 (4.8, 5.2, 6.0 and 7.0 kb) fragments and a 3.2 kb DQB1 fragment to be significantly increased in Caucasians with seropositive RA compared to healthy individuals.
|
2576478 |
1989 |