Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells. 28330870

2017

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 GeneticVariation BEFREE IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model. 28714957

2017

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker CTD_human These findings indicate that the Nrf2-mediated suppression of apoptosis and promotion of autophagy contribute to nickel-induced transformation and tumorigenesis. 28330870

2017

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker CTD_human Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells. 28330870

2017

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Effects of Nrf2 silencing on oxidative stress-associated intestinal carcinogenesis in mice. 26899729

2017

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Our findings stress the dual role of Nrf2 in carcinogenesis, while offering approaches to exploit Nrf2 as a potent therapeutic target in ovarian cancer. 25841766

2016

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Antioncogenic and Oncogenic Properties of Nrf2 in Arsenic-induced Carcinogenesis. 26385919

2016

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Nrf2 and TGF-β1 both affect tumorigenesis in a dual fashion, either by preventing carcinogen induced carcinogenesis and suppressing tumor growth, respectively, or by conferring cytoprotection and invasiveness to tumor cells during malignant transformation. 26226105

2016

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Because the cancer initiating mutations in these hereditary syndromes are well defined, they offer a unique opportunity to explore the roles of NRF2 activation in the early stages of carcinogenesis. 26551707

2016

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Functional Role of NRF2 in Cervical Carcinogenesis. 26247201

2016

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 AlteredExpression BEFREE Overall, our results reveal an unexpected tumor-promoting activity of activated NRF2 during early phases of skin tumorigenesis. 26530903

2016

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde. 25712056

2016

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 GeneticVariation BEFREE While association studies with genetic NRF2 polymorphisms supported a protective role for murine Nrf2 in oxidative airway diseases, somatic NRF2 mutations enhanced NRF2-ARE responses, and were favorable for lung carcinogenesis and chemoresistance. 26194645

2016

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Among the CNC family members, NRF2 is required for systemic protection against redox-mediated injury and carcinogenesis. 25458917

2016

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 AlteredExpression BEFREE Collectively, these data show that Nrf2 is not a driver for tumorigenesis even upon exposure to a very potent and complete carcinogen and strongly suggest that the frequent activation of Nrf2 in established human tumors is a marker of metabolic adaptation. 25804610

2016

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 AlteredExpression BEFREE We recently showed that KSHV infection of endothelial cells activates the transcription factor Nrf2 to promote an environment conducive to infection and oncogenesis. 25995248

2015

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE A key role for Nrf2 in ovarian carcinogenesis has been validated by siRNA studies. 25270772

2015

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 GeneticVariation BEFREE Owing to its cytoprotective functions, Nrf2 has been traditionally studied in the field of chemoprevention; however, there is accumulated evidence that Keap1/Nrf2 mutations or unbalanced regulation that leads to overexpression or hyperactivation of Nrf2 may participate in tumorigenesis and be involved in chemoresistance of a wide number of solid cancers and leukemias. 23820265

2015

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Nrf2/p62 signaling in apoptosis resistance and its role in cadmium-induced carcinogenesis. 25157103

2015

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 PosttranslationalModification BEFREE To understand the transcriptional regulation of p73 by promoter methylation and Nrf-2 in breast carcinogenesis, ChIP assay indicated that Nrf-2 can bind to both promoters and can activate the transcription of TAp73 and ΔNp73 in MCF-7 cell line, knockdown of Nrf-2 gene resulted in an abrogation of TAp73 and ΔNp73 expression in the cells transfected with sh-Nrf-2 as well as Nrf-2 knock out mouse model. 25071010

2015

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE The PTEN/NRF2 axis promotes human carcinogenesis. 24892215

2015

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 PosttranslationalModification BEFREE Inhibition of E2-mediated alterations in NRF2 promoter methylation and expression of NRF2 targeting miR-93 after Res treatment indicated Res-mediated epigenetic regulation of NRF2 during E2-induced breast carcinogenesis. 24894866

2015

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 GeneticVariation BEFREE We discovered that early tumorigenesis in Braf(V600E)-driven lung cancer is accelerated by autophagy ablation due to unmitigated oxidative stress, as observed with loss of Nfe2l2/Nrf2-mediated antioxidant defense. 24362353

2014

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Similar to NRF2, the tumor suppressor Homologous to the E6-AP Carboxyl Terminus (HECT) domain and Ankyrin repeat containing E3 ubiquitin-protein ligase 1 (HACE1) plays a protective role against stress-induced tumorigenesis in mice, but its roles in the antioxidative stress response or its involvement in neurodegeneration have not been investigated. 24516159

2014

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.400 Biomarker BEFREE Although nuclear factor E2-related factor-2 (Nrf2) protects from carcinogen-induced tumorigenesis, underlying the rationale for using Nrf2 inducers in chemoprevention, this antioxidative transcription factor may also act as a proto-oncogene. 24311782

2014