×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Brain Stem Glioma
0.120
AlteredExpression
BEFREE
Immunofluorescence of p53 was shown activated following BGSC s differentiation.
29937714 2018
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Brain Stem Glioma
0.120
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Brain Stem Glioma
0.120
Biomarker
BEFREE
We utilized a genetic brainstem glioma mouse model driven by platelet-derived growth factor-B and p53 loss using abcg2/abcb1 wild-type (ABC WT) or abcg2/abcb1 knockout mice (ABC KO).
26883271 2016
×
Entrez Id: 90
Gene Symbol: ACVR1
ACVR1
Brain Stem Glioma
0.100
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
Brain Stem Glioma
0.100
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 3020
Gene Symbol: H3-3A
H3-3A
Brain Stem Glioma
0.100
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Brain Stem Glioma
0.100
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Brain Stem Glioma
0.100
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
Brain Stem Glioma
0.100
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Brain Stem Glioma
0.100
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
Brain Stem Glioma
0.100
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 8354
Gene Symbol: H3C11
H3C11
Brain Stem Glioma
0.100
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 5077
Gene Symbol: PAX3
PAX3
Brain Stem Glioma
0.030
Biomarker
BEFREE
Then, the function of PAX3 in BGSC s were sequentially investigated <i>in vitro</i> and <i>in vivo</i>.
29937714 2018
×
Entrez Id: 5077
Gene Symbol: PAX3
PAX3
Brain Stem Glioma
0.030
AlteredExpression
BEFREE
The results indicate that Pax3 regulates GFAP expression, and that Pax3 may contribute to the evolution of BGSC s towards malignancy.
27432276 2016
×
Entrez Id: 5077
Gene Symbol: PAX3
PAX3
Brain Stem Glioma
0.030
AlteredExpression
BEFREE
Collectively, these data suggest that regional Pax3 expression not only marks a novel subset of BSG but also contributes to PDGF-B-induced brainstem gliomagenesis.
25330836 2014
×
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
Brain Stem Glioma
0.010
Biomarker
BEFREE
In addition, hypoxia inducible factor-1α (HIF-1α ) might be a potential upstream regulator of PAX3 in differentiated BGSC s under hypoxia.
29937714 2018
×
Entrez Id: 10215
Gene Symbol: OLIG2
OLIG2
Brain Stem Glioma
0.010
Biomarker
BEFREE
Here we report that Olig2 expression and DIPG differentiation are mutually exclusive events in vitro, and only DIPG cells that retained Olig2 in vitro formed robust Olig2 -positive brainstem glioma with 100% penetrance in a xenograft model.
28339768 2017
×
Entrez Id: 29126
Gene Symbol: CD274
CD274
Brain Stem Glioma
0.010
Biomarker
BEFREE
PD-L1 staining was detected in 59.7% of brainstem glioma specimens (37/62).29137285 2017
×
Entrez Id: 8842
Gene Symbol: PROM1
PROM1
Brain Stem Glioma
0.010
Biomarker
BEFREE
Development of a novel imaging agent using peptide-coated gold nanoparticles toward brain glioma stem cell marker CD133 .
27721007 2017
×
Entrez Id: 10058
Gene Symbol: ABCB6
ABCB6
Brain Stem Glioma
0.010
Biomarker
BEFREE
Elacridar, an ABCG2 and ABCB1 inhibitor, significantly increases the efficacy of dasatinib in brainstem glioma -bearing ABC WT mice (42 vs. 59 days).
26883271 2016
×
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
Brain Stem Glioma
0.010
Biomarker
BEFREE
Elacridar, an ABCG2 and ABCB1 inhibitor, significantly increases the efficacy of dasatinib in brainstem glioma -bearing ABC WT mice (42 vs. 59 days).
26883271 2016
×
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Brain Stem Glioma
0.010
Biomarker
BEFREE
Elacridar, an ABCG2 and ABCB1 inhibitor, significantly increases the efficacy of dasatinib in brainstem glioma -bearing ABC WT mice (42 vs. 59 days).
26883271 2016
×
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
Brain Stem Glioma
0.010
AlteredExpression
BEFREE
The results indicate that Pax3 regulates GFAP expression, and that Pax3 may contribute to the evolution of BGSC s towards malignancy.
27432276 2016
×
Entrez Id: 8932
Gene Symbol: MBD2
MBD2
Brain Stem Glioma
0.010
GeneticVariation
BEFREE
Our results demonstrate that increasing H3K27 methylation by inhibiting K27 demethylase is a valid therapeutic strategy for treating K27M -expressing brainstem glioma .
25401693 2014
×
Entrez Id: 10763
Gene Symbol: NES
NES
Brain Stem Glioma
0.010
Biomarker
BEFREE
In an effort to elucidate unique characteristics of BSG, we conducted expression analysis of mouse PDGF-B-driven BSG and CG initiated in Nestin progenitor cells and identified a short list of expression changes specific to the brainstem gliomagenesis process, including abnormal upregulation of paired box 3 (Pax3).
25330836 2014