Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE The consequent upregulation of nuclear FoxO3a and its binding to the Bmi-1 promoter, may account for the self-renewal activity of breast cancer stem-like cells and their growth in a xenograft mouse model. 31672029

2020

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE Co-expression of FUNDC1 and BMI1 in BC patients predicted worse prognosis than without either expression. 30803933

2019

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE Thus, inhibition of BMI1 expression particularly in breast cancer stem cells can be used as a potential strategy for the complete elimination of tumor and to prevent disease relapse. 30096458

2018

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE Regulating BMI1 expression via miRNAs promote Mesenchymal to Epithelial Transition (MET) and sensitizes breast cancer cell to chemotherapeutic drug. 29394261

2018

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE Our data shows that PHGDH deficiency impairs the tumorsphere formation capacity in embryonal carcinoma stem-like cells (ECSLCs), breast cancer stem-like cells (BCSLCs) and patient-derived brain tumor-initiating cells (BTICs), which is accompanied by the reduced expression of characteristic stemness-promoting factors, such as Oct4, Nanog, Sox-2, and Bmi-1. 30250195

2018

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE With a series of biology approaches, subsequently, we proved that BMI1 was a functional downstream target of miR-630 and mediated the property of miR-630-dependent inhibition of breast cancer progression. 29208462

2018

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE Polycomb group (PcG) protein BMI1 is an important regulator of oncogenic phenotype and is often overexpressed in several human malignancies including breast cancer. 29528145

2018

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 GeneticVariation BEFREE Association of ATM and BMI-1 genetic variation with breast cancer risk in Han Chinese. 29691986

2018

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE Erratum: miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin. 29018209

2017

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE These results show that inhibiting Bmi1 expression in breast cancer stem cells could be important for the complete elimination of tumor and potentially preventing disease relapse. 28418883

2017

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE In the present study, we further demonstrated that 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), an inhibitor of Hsp90, could suppress the self-renewal of BCSCs by downregulating B lymphoma Mo-MLV insertion region 1 homolog (BMI1), a polycomb family member with oncogenic activity in breast cancer. 28914785

2017

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin. 28655885

2017

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE BMI-1 Promotes Self-Renewal of Radio- and Temozolomide (TMZ)-Resistant Breast Cancer Cells. 28270035

2017

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE Hinokitiol up-regulates miR-494-3p to suppress BMI1 expression and inhibits self-renewal of breast cancer stem/progenitor cells. 29100291

2017

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE According to our data, significant elevation of the expression of miR-218 and downregulation of BMI1 were observed in clinical breast cancer specimens compared with normal tissues ( p < 0.0001). 28857013

2017

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE Our results demonstrate that BMI1 is an important therapeutic target in breast cancer and suppression of BMI1 produces radiation sensitivity. 28260023

2017

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE We also show that PTC-209, a small molecule inhibitor of BMI1 gene expression induces cellular senescence and transcriptionally upregulates expression of miR-200c/141 cluster in breast cancer cells. 27105531

2016

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE Here we have made an endeavor to search whether any miRNAs are involved in the regulation of BMI1 in breast cancer that leads to mitochondrial dependent apoptotic cell death. 27596816

2016

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE This study not only bridges the missing link between stem cell-related transcription factor (Bmi1) and ABC transporter (ABCC5) but also contributes to development of potential therapeutics against breast cancer. 26546432

2016

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE Nanoparticle siRNA against BMI-1 with a Polyethylenimine-Laminarin Conjugate for Gene Therapy in Human Breast Cancer. 26629893

2016

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE The PANDAR/Bmi1/p16(INK4A) axis could serve as novel targets for breast cancer therapy. 26927017

2016

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE The role of polycomb group protein Bmi-1 and Notch4 in breast cancer stem cell inhibition by benzyl isothiocyanate. 25663545

2015

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE In Caucasian populations, high expression of Bmi-1 was associated with better OS in breast cancer (HR=0.70, 95% CI 0.51-0.97), but it showed no significance in oesophageal carcinoma. 25458792

2014

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression BEFREE Regulation of B cell-specific Moloney murine leukaemia virus integration site 1 (BMI1) expression with increase in histological grades of breast carcinoma in correlation with hormone receptor status was studied in 60 Indian breast cancer patient's formalin-fixed paraffin-embedded tissue blocks. 23873108

2013

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE Thus, our study suggests a cross-talk between Bmi1 and miR-200c mediated by p53, and Bmi1 interference would improve chemotherapy efficiency in breast cancer via susceptive apoptosis induction and cancer stem cell enrichment inhibition. 24039897

2013