To explore the correlation of expression of long non-coding RNA (lncRNA) zinc finger E-box binding homeobox 2 antisense RNA 1 (ZEB2-AS1) in gastric cancer tissues, analyze the correlations of its expression level with the clinicopathological features of gastric cancer and the malignant phenotype of tumor cells, and investigate the molecular mechanism of action of ZEB2-AS1 in gastric cancer.
In summary, TGF-β/ZEB2 axis plays an encouraging role in trastuzumab resistance of gastric cancer, while miR-200c overexpression downregulates ZEB1/ZEB2 and resensitizes drugs resistance.
The elevated ARK5 expression was closely associated with cancer metastasis and patient survival, and it seemed to function in GC cells migration and invasion via EMT alteration, together with the alteration of the mTOR/p70S6k signals, Slug and SIP1, thus providing a potential therapeutic target for GC.
For intestinal type gastric cancer in particular, elevated SIP1 expression was significantly correlated with peritoneal dissemination and poor prognosis (p < 0.05).